Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii
文献类型：期刊论文
| 作者 | Zong, Jian-Fa1; Zhang, Meng-Meng2; Zhou, Yu-Bo2 ; Li, Jia2; Hou, Ai-Jun1; Lei, Chun1
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2021-09-01 |
| 卷号 | 153页码:5 |
| 关键词 | Hypericum forrestii (Chittenden) N Robson Clusiaceae Acylphloroglucinol meroterpenoid Hyperiforins A-C Protein tyrosine phosphatase 1B |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2021.104959 |
| 通讯作者 | Hou, Ai-Jun(ajhou@shmu.edu.cn) ; Lei, Chun(chunlei@fudan.edu.cn) |
| 英文摘要 | Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C (1-3), were isolated from Hypericum forrestii (Chittenden) N. Robson, together with twelve known analogues (4-15). Their structures were established by extensive physical and spectroscopic data analysis. Compounds 1, 2, 5, 7, and 13-15 showed potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values from 6.63 +/- 2.40 to 14.21 +/- 3.51 is mu M. |
| WOS关键词 | A-H ; DERIVATIVES ; PHLOROGLUCINOL ; HYPERFORIN ; SKELETON ; ANALOGS |
| 资助项目 | National Natural Science Foundation of China[21672040] ; National Natural Science Foundation of China[82073717] ; Science and Technology Commission of Shanghai Municipality[20S21900600] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000684861800009 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297943]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Hou, Ai-Jun; Lei, Chun |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zong, Jian-Fa,Zhang, Meng-Meng,Zhou, Yu-Bo,et al. Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii[J]. FITOTERAPIA,2021,153:5. |
| APA | Zong, Jian-Fa,Zhang, Meng-Meng,Zhou, Yu-Bo,Li, Jia,Hou, Ai-Jun,&Lei, Chun.(2021).Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii.FITOTERAPIA,153,5. |
| MLA | Zong, Jian-Fa,et al."Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii".FITOTERAPIA 153(2021):5. |
入库方式： OAI收割
来源：上海药物研究所
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