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Noreudesmane sesquiterpenoids from Artemisia hedinii and their anti-inflammatory activities

文献类型：期刊论文

作者Wang, Xing1,2,3; Tang, Chunping1,2; Meng, Suoriya1,2,3; Tang, Bixi1,2,4; Zang, Yi1,2,3,5; Ke, Chang-Qiang1,2; Yao, Sheng1,2,3; Li, Jia1,2,3,5,6; Ye, Yang1,2,3,7
刊名FITOTERAPIA
出版日期2021-09-01
卷号153页码:9
关键词Artemisia hedinii Sesquiterpenoid Dinoreudesmane Trinoreudesmane Anti-inflammatory activity
ISSN号0367-326X
DOI10.1016/j.fitote.2021.104961
通讯作者Ye, Yang(yye@simm.ac.cn)
英文摘要Ten undescribed noreudesmane-type sesquiterpenoids, including eight 12,13-dinoreudesmanes and a pair of 11,12,13-trinoreudesmane epimers were isolated from the whole plant of Artemisia hedinii. Their structures were elucidated by extensive analysis of spectroscopic data, including MS, 1D and 2D NMR, and their absolute con -figurations were confirmed by X-ray diffraction experiments and DFT calculations. Compounds 1-5, 7-10 were evaluated for their anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated murine macrophages RAW264.7 cells, and all of them could significantly inhibit the LPS induced CCL2 mRNA expression in a dose-dependent manner.
WOS关键词EUDESMANE SESQUITERPENES ; PYRUVATE DECARBOXYLASE ; INHIBITORY-ACTIVITY ; ALPINIA-OXYPHYLLA ; COENZYME-A ; CONSTITUENTS ; DERIVATIVES ; PATHWAY ; LEAVES
资助项目Ministry of Science and Technology of the People's Republic of China[2017YFE0195100] ; Science and Technology Commission of Shanghai Municipality[19431908100] ; Science and Technology Commission of Shanghai Municipality[20430780300]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000684861800003
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/297946]  
专题新药研究国家重点实验室
通讯作者Ye, Yang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 201203, Peoples R China
5.UCAS, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China
6.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xing,Tang, Chunping,Meng, Suoriya,et al. Noreudesmane sesquiterpenoids from Artemisia hedinii and their anti-inflammatory activities[J]. FITOTERAPIA,2021,153:9.
APA Wang, Xing.,Tang, Chunping.,Meng, Suoriya.,Tang, Bixi.,Zang, Yi.,...&Ye, Yang.(2021).Noreudesmane sesquiterpenoids from Artemisia hedinii and their anti-inflammatory activities.FITOTERAPIA,153,9.
MLA Wang, Xing,et al."Noreudesmane sesquiterpenoids from Artemisia hedinii and their anti-inflammatory activities".FITOTERAPIA 153(2021):9.

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来源：上海药物研究所

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