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NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms

文献类型：期刊论文

作者Zhou, Zikai1,2,3,4,5,8; He, Guiqin1,2; Zhang, Xiaoyun3,4,5; Lv, Xin1; Zhang, Xiaolin1; Liu, An2; Xia, Shuting2,6,7; Xie, Hao2; Dang, Rui2; Han, Lifang2
刊名CELL REPORTS
出版日期2021-08-17
卷号36期号:7页码:20
ISSN号2211-1247
DOI10.1016/j.celrep.2021.109515
通讯作者Zhou, Zikai(zhouzikai@simm.ac.cn) ; Jia, Zhengping(zhengping.jia@sickkids.ca)
英文摘要Synaptic scaling is an extensively studied form of homeostatic plasticity critically involved in various brain functions. Although it is accepted that synaptic scaling is expressed through the postsynaptic accumulation of AMPA receptors (AMPARs), the induction mechanism remains elusive. In this study, we show that TTX treatment induces rapid but transient release of the neurite growth-promoting factor 2 (NGPF2), and this release is necessary and sufficient for TTX-induced scaling up. In addition, we show that inhibition of the anaplastic lymphoma kinase (ALK)-LIMK-cofilin signaling pathway blocks TTX- and NGPF2-induced synaptic scaling up. Furthermore, we show that TTX-induced release of NGPF2 is protein synthesis dependent and requires fragile X mental retardation protein 1 (FMRP1). These results indicate that activity blockade induces NGPF2 synthesis and release to trigger synaptic scaling up through LIMK-cofilin-dependent actin reorganization, spine enlargement, and stabilization of AMPARs at the synapse.
WOS关键词ANAPLASTIC LYMPHOMA KINASE ; RECEPTOR TYROSINE KINASE ; AMPA RECEPTOR ; RETINOIC ACID ; HOMEOSTATIC PLASTICITY ; QUANTAL AMPLITUDE ; MICE DEFICIENT ; MIDKINE MK ; EXPRESSION ; ACTIN
资助项目National Natural Science Foundation of China[81971022] ; Canadian Institutes of Health Research[PJT155959] ; Canadian Institutes of Health Research[PJT168922] ; Canadian Natural Science and Engineering Research Council[RGPIN341498] ; Canadian Natural Science and Engineering Research Council[RGPIN06295] ; Program of Shanghai Academic Research Leader[19XD1423300] ; China Postdoctoral Science Foundation[2018M642036] ; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine grant Support[20191835] ; Science and Technology Commission of Shanghai Municipality[201409002600] ; Shanghai Mental Health CenterClinical Research Center[CRC2019ZD01]
WOS研究方向Cell Biology
语种英语
出版者CELL PRESS
WOS记录号WOS:000686356500002
源URL[http://119.78.100.183/handle/2S10ELR8/297955]  
专题新药研究国家重点实验室
通讯作者Zhou, Zikai; Jia, Zhengping
作者单位1.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai, Peoples R China
2.Southeast Univ, Sch Life Sci & Technol, 2 Sipailou Rd, Nanjing 210096, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Inst Drug Discovery, Zhongshan, Peoples R China
5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Inst Dev, Zhongshan, Peoples R China
6.Hosp Sick Children, Neurosci & Mental Hlth, 555 Univ Ave, Toronto, ON M5G 1X8, Canada
7.Univ Toronto, Fac Med, Dept Physiol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada
8.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Zikai,He, Guiqin,Zhang, Xiaoyun,et al. NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms[J]. CELL REPORTS,2021,36(7):20.
APA Zhou, Zikai.,He, Guiqin.,Zhang, Xiaoyun.,Lv, Xin.,Zhang, Xiaolin.,...&Jia, Zhengping.(2021).NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms.CELL REPORTS,36(7),20.
MLA Zhou, Zikai,et al."NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms".CELL REPORTS 36.7(2021):20.

入库方式： OAI收割

来源：上海药物研究所

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