Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans
文献类型：期刊论文
| 作者 | Xu, Zhuojia1,2; Deng, Yaqi1; Zhang, Zhumin1; Ma, Wenjing1,2; Li, Wanjin1; Wen, Liuqing1; Li, Tiehai1,3 |
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2021-08-06 |
| 卷号 | 86期号:15页码:10819-10828 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.1c01115 |
| 通讯作者 | Wen, Liuqing(lwen@simm.ac.cn) ; Li, Tiehai(tiehaili@simm.ac.cn) |
| 英文摘要 | A diversity-oriented chemoenzymatic approach for the collective preparation of sulfated core 2 O-GalNAc glycans and their nonsulfated counterparts was described. A sulfated trisaccharide and a nonsulfated trisaccharide were chemically synthesized by combining flexible protected group manipulations and sequential one-pot glycosylations. The divergent enzymatic extension of these two trisaccharides, using a panel of robust glycosyltransferases that can recognize sulfated substrates and differentiating the branches with specifically designed glycosylation sequences to achieve regioselective sialylation, provided 36 structurally well-defined O-GalNAc glycans. |
| WOS关键词 | EFFICIENT SYNTHESIS ; SELECTIVE SYNTHESIS ; BUILDING-BLOCK ; GLYCOSYLATION ; PSGL-1 ; GLYCOPEPTIDE ; STRATEGY |
| 资助项目 | National Natural Science Foundation of China[22077130] ; National Natural Science Foundation of China[22007092] ; Shanghai Pujiang Program[20PJ1415800] ; Science and Technology Commission of Shanghai Municipality[20ZR1467900] ; Shanghai Municipal Science and Technology Major Project ; Shanghai Sailing Program[20YF1457200] ; State Key Laboratory of Medicinal Chemical Biology of Nankai University[2020013] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000684025500074 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298070]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wen, Liuqing; Li, Tiehai |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Zhuojia,Deng, Yaqi,Zhang, Zhumin,et al. Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(15):10819-10828. |
| APA | Xu, Zhuojia.,Deng, Yaqi.,Zhang, Zhumin.,Ma, Wenjing.,Li, Wanjin.,...&Li, Tiehai.(2021).Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans.JOURNAL OF ORGANIC CHEMISTRY,86(15),10819-10828. |
| MLA | Xu, Zhuojia,et al."Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans".JOURNAL OF ORGANIC CHEMISTRY 86.15(2021):10819-10828. |
入库方式： OAI收割
来源：上海药物研究所
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