Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis
文献类型：期刊论文
| 作者 | Chen, Zi-Hui1,2; Li, Wang-Sheng1,3; Zhang, Zai-Yong1; Luo, Hui3; Wang, Jian-Rong1 ; Zhang, Hai-Yan4; Zeng, Zi-Rong1; Chen, Bao1; Li, Xu-Wen1,2; Guo, Yue-Wei1,2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021-08-06 |
| 卷号 | 23期号:15页码:5621-5625 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c01601 |
| 通讯作者 | Zhang, Hai-Yan(hzhang@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | A novel norditerpenoid, sinusiaetone A (1), featuring an uncommon bicyclo[11.3.0]hexadecane carbon skeleton, and four polyoxygenated cembranoids (2-5) were isolated from the Hainan soft coral Sinularia siaesensis. Their structures were established by spectroscopic analysis, X-ray diffraction, quantum chemical computational approaches, and/or a modified Mosher's method. A plausible biosynthetic pathway of 1 and its biogenetic relationship with 2-5 were proposed. New compounds 1-3 displayed an interesting inhibitory activity against lipopolysaccharide-induced inflammation in BV-2 microglial cells. |
| WOS关键词 | DITERPENOIDS |
| 资助项目 | National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[82022069] ; National Natural Science Foundation of China[42076099] ; National Key Research and Development Program of China[2018YFC0310903] ; Shanghai RisingStar Program[20QA1411100] ; Youth Innovation Promotion Association of CAS[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ-06] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000684033200006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298073]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Hai-Yan; Li, Xu-Wen; Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangdong Med Univ, Marine Biomed Res Inst, Key Lab Zhanjiang R&D Marine Microbial Resources, Zhanjiang 524023, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Zi-Hui,Li, Wang-Sheng,Zhang, Zai-Yong,et al. Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis[J]. ORGANIC LETTERS,2021,23(15):5621-5625. |
| APA | Chen, Zi-Hui.,Li, Wang-Sheng.,Zhang, Zai-Yong.,Luo, Hui.,Wang, Jian-Rong.,...&Guo, Yue-Wei.(2021).Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis.ORGANIC LETTERS,23(15),5621-5625. |
| MLA | Chen, Zi-Hui,et al."Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis".ORGANIC LETTERS 23.15(2021):5621-5625. |
入库方式： OAI收割
来源：上海药物研究所
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