Spiro ent-Clerodane Dimers: Discovery and Green Approaches for a Scalable Biomimetic Synthesis
文献类型：期刊论文
| 作者 | Li, Xing-Ren2,3; Yan, Bing-Chao2,3; Hu, Kun2,3; He, Shijun1,4 ; Sun, Han-Dong2,3; Zuo, Jianping1,4; Puno, Pema-Tenzin2,3
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021-08-06 |
| 卷号 | 23期号:15页码:5647-5651 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c01724 |
| 通讯作者 | Puno, Pema-Tenzin(punopematenzin@mail.kib.ac.cn) |
| 英文摘要 | Scospirosins A (1) and B (2), two unprecedented Spiro ent-derodane dimers with 6/6/10/6 and 6/6/6/6/6 ring systems, respectively, were isolated from Isodon scoparius. Their structures were unambiguously established by spectroscopic, X-ray crystallographic, and chemical approaches. A bioinspired protecting-group-free strategy for their synthesis was achieved on a gram scale and featured the application of green methods, including neat reaction, sensitized photooxygenation, and electrochemical oxidation. 2 exhibited selective immunosuppressive activity against the proliferation of T lymphocytes (IC50 = 1.42 mu M). |
| WOS关键词 | DIELS-ALDER REACTIONS ; SENSITIZED PHOTOOXYGENATION ; NATURAL-PRODUCTS ; ACID ; DITERPENOIDS |
| 资助项目 | NSFC-Joint Foundation of Yunnan Province[U2002221] ; Second Tibetan Plateau Scientific Expedition and Research (STEP) program[2019QZKK0502] ; National Natural Science Foundation of China[81673329] ; National Natural Science Foundation of China[81874298] ; CAS Interdisciplinary Innovation Team ; Yunnan Science Fund for Distinguished Young Scholars[2019FJ002] ; CAS Light of West China Program |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000684033200011 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298091]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Puno, Pema-Tenzin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xing-Ren,Yan, Bing-Chao,Hu, Kun,et al. Spiro ent-Clerodane Dimers: Discovery and Green Approaches for a Scalable Biomimetic Synthesis[J]. ORGANIC LETTERS,2021,23(15):5647-5651. |
| APA | Li, Xing-Ren.,Yan, Bing-Chao.,Hu, Kun.,He, Shijun.,Sun, Han-Dong.,...&Puno, Pema-Tenzin.(2021).Spiro ent-Clerodane Dimers: Discovery and Green Approaches for a Scalable Biomimetic Synthesis.ORGANIC LETTERS,23(15),5647-5651. |
| MLA | Li, Xing-Ren,et al."Spiro ent-Clerodane Dimers: Discovery and Green Approaches for a Scalable Biomimetic Synthesis".ORGANIC LETTERS 23.15(2021):5647-5651. |
入库方式： OAI收割
来源：上海药物研究所
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