Stereoselective Synthesis of beta-C-Glycosides of 3-Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) via SmI2-Mediated Reformatsky Reactions
文献类型：期刊论文
| 作者 | Zhang, Zhumin1; Xu, Zhuojia1,2; Liu, Xingbang1; Luo, Shiwei1,3; Li, Tiehai1,4 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021-08-06 |
| 卷号 | 23期号:15页码:6090-6093 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c02158 |
| 通讯作者 | Li, Tiehai(tiehaili@simm.ac.cn) |
| 英文摘要 | An efficient and simple approach for stereoselective synthesis of beta-Kdo C-glycosides was described, which relies on easily available peracetylated anomeric acetate or anomeric 2-pyridyl sulfide to couple with carbonyl compounds via SmI2-mediated Reformatsky reactions. The utility of this methodology is exemplified by the streamlined synthesis of a practical beta-Kdo C-glycoside with an anomeric aminopropyl linker to conjugate with other biomolecules for further biological studies. |
| WOS关键词 | 3-DEOXY-D-MANNO-2-OCTULOSONIC ACID ; EXOPOLYSACCHARIDE ; ANALOG |
| 资助项目 | National Natural Science Foundation of China[22077130] ; Shanghai Pujiang Program[20PJ1415800] ; Science and Technology Commission of Shanghai Municipality[20ZR1467900] ; Shanghai Municipal Science and Technology Major Project ; State Key Laboratory of Medicinal Chemical Biology of Nankai University[2020013] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000684033200078 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298116]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Tiehai |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhumin,Xu, Zhuojia,Liu, Xingbang,et al. Stereoselective Synthesis of beta-C-Glycosides of 3-Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) via SmI2-Mediated Reformatsky Reactions[J]. ORGANIC LETTERS,2021,23(15):6090-6093. |
| APA | Zhang, Zhumin,Xu, Zhuojia,Liu, Xingbang,Luo, Shiwei,&Li, Tiehai.(2021).Stereoselective Synthesis of beta-C-Glycosides of 3-Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) via SmI2-Mediated Reformatsky Reactions.ORGANIC LETTERS,23(15),6090-6093. |
| MLA | Zhang, Zhumin,et al."Stereoselective Synthesis of beta-C-Glycosides of 3-Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) via SmI2-Mediated Reformatsky Reactions".ORGANIC LETTERS 23.15(2021):6090-6093. |
入库方式： OAI收割
来源：上海药物研究所
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