Ketogenesis impact on liver metabolism revealed by proteomics of lysine beta-hydroxybutyrylation
文献类型：期刊论文
| 作者 | Koronowski, Kevin B.2; Greco, Carolina M.2; Huang, He1,3; Kim, Jin-Kwang4; Fribourgh, Jennifer L.5,6; Crosby, Priya5,6; Mathur, Lavina2; Ren, Xuelian1; Partch, Carrie L.5,6; Jang, Cholsoon2 |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2021-08-03 |
| 卷号 | 36期号:5页码:17 |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2021.109487 |
| 通讯作者 | Koronowski, Kevin B.(kkoronow@hs.uci.edu) ; Greco, Carolina M.(grecoc@hs.uci.edu) |
| 英文摘要 | Ketone bodies are bioactive metabolites that function as energy substrates, signaling molecules, and regulators of histone modifications. beta-hydroxybutyrate (beta-OHB) is utilized in lysine beta-hydroxybutyrylation (Kbhb) of histones, and associates with starvation-responsive genes, effectively coupling ketogenic metabolism with gene expression. The emerging diversity of the lysine acylation landscape prompted us to investigate the full proteomic impact of Kbhb. Global protein Kbhb is induced in a tissue-specific manner by a variety of interventions that evoke beta-OHB. Mass spectrometry analysis of the beta-hydroxybutyrylome in mouse liver revealed 891 sites of Kbhb within 267 proteins enriched for fatty acid, amino acid, detoxification, and one-carbon metabolic pathways. Kbhb inhibits S-adenosyl-L-homocysteine hydrolase (AHCY), a rate-limiting enzyme of the methionine cycle, in parallel with altered metabolite levels. Our results illuminate the role of Kbhb in hepatic metabolism under ketogenic conditions and demonstrate a functional consequence of this modification on a central metabolic enzyme. |
| WOS关键词 | S-ADENOSYLHOMOCYSTEINE HYDROLASE ; HISTONE ACETYLATION ; FUEL METABOLISM ; GENE-EXPRESSION ; KETONE-BODIES ; PROTEIN ; DIET ; IDENTIFICATION ; TRANSCRIPTION ; EPIGENETICS |
| 资助项目 | NIH[R01GM115961] ; NIH[R01DK107868] ; NIH[R01DK118266] ; NIH[R21DK114652] ; NIH[R21AG053592] ; Novo Nordisk Foundation[NNF-202585] ; NIH-NINDS[T32 5T32NS045540] ; NIH-NINDS[F32DK121425] ; National Cancer Institute of the U.S. National Institutes of Health[NIH T32 2T32CA009054-36A1] ; European Research Council[ERC MSCA-IF-2016 MetEpiClock 749869] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000681653300022 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298153]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Koronowski, Kevin B.; Greco, Carolina M. |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Calif Irvine, Ctr Epigenet & Metab, U1233 INSERM, Dept Biol Chem, Irvine, CA 92697 USA 3.Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA 4.Univ Calif Irvine, Dept Biol Chem, Irvine Sch Med, Irvine, CA 92697 USA 5.Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA 6.Univ Calif San Diego, Ctr Circadian Biol, La Jolla, CA 92093 USA |
| 推荐引用方式 GB/T 7714 | Koronowski, Kevin B.,Greco, Carolina M.,Huang, He,et al. Ketogenesis impact on liver metabolism revealed by proteomics of lysine beta-hydroxybutyrylation[J]. CELL REPORTS,2021,36(5):17. |
| APA | Koronowski, Kevin B..,Greco, Carolina M..,Huang, He.,Kim, Jin-Kwang.,Fribourgh, Jennifer L..,...&Sassone-Corsi, Paolo.(2021).Ketogenesis impact on liver metabolism revealed by proteomics of lysine beta-hydroxybutyrylation.CELL REPORTS,36(5),17. |
| MLA | Koronowski, Kevin B.,et al."Ketogenesis impact on liver metabolism revealed by proteomics of lysine beta-hydroxybutyrylation".CELL REPORTS 36.5(2021):17. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。