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Structural Characterization of a Polysaccharide from Gastrodia elata and Its Bioactivity on Gut Microbiota

文献类型：期刊论文

作者Huo, Jiangyan1,2; Lei, Min1,2; Li, Feifei1,2; Hou, Jinjun1,2; Zhang, Zijia1,2; Long, Huali1,2; Zhong, Xianchun1,2; Liu, Yameng1,2; Xie, Cen1,2; Wu, Wanying1,2
刊名MOLECULES
出版日期2021-08-01
卷号26期号:15页码:11
关键词Gastrodia elata structural characterization polysaccharide gut microbiota
DOI10.3390/molecules26154443
通讯作者Xie, Cen(xiecen@simm.ac.cn) ; Wu, Wanying(wanyingwu@simm.ac.cn)
英文摘要A novel homogeneous polysaccharide named GEP-1 was isolated and purified from Gastrodia elata (G. elata) by hot-water extraction, ethanol precipitation, and membrane separator. GEP-1, which has a molecular weight of 20.1 kDa, contains a polysaccharide framework comprised of only glucose. Methylation and NMR analysis showed that GEP-1 contained 1,3,6-linked-alpha-Glcp, 1,4-linked-alpha-Glcp, 1,4-linked-beta-Glcp and 1,4,6-linked-alpha-Glcp. Interestingly, GEP-1 contained citric acid and repeating p-hydroxybenzyl alcohol as one branch. Furthermore, a bioactivity test showed that GEP-1 could significantly promote the growth of Akkermansia muciniphila (A. muciniphila) and Lacticaseibacillus paracasei (L. paracasei) strains. These results implied that GEP-1 might be useful for human by modulating gut microbiota.
WOS关键词RADICAL SCAVENGING ACTIVITIES ; CONSTITUENTS ; EXTRACTION ; EPILEPSY ; RHIZOMES ; BLUME ; BL
资助项目Special Fund for National Key R&D Program of China[2018YFC1707001] ; Special Fund for National Key R&D Program of China[2018YFC1707900] ; Special Fund for National Key R&D Program of China[2018YFC1707903] ; Special Fund for National Key R&D Program of China[2018YFC1707905] ; Research Project of Science and Technology Commission of Shanghai Municipality[18DZ2200800]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000682301200001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/298162]  
专题中国科学院上海药物研究所
通讯作者Xie, Cen; Wu, Wanying
作者单位1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Huo, Jiangyan,Lei, Min,Li, Feifei,et al. Structural Characterization of a Polysaccharide from Gastrodia elata and Its Bioactivity on Gut Microbiota[J]. MOLECULES,2021,26(15):11.
APA Huo, Jiangyan.,Lei, Min.,Li, Feifei.,Hou, Jinjun.,Zhang, Zijia.,...&Wu, Wanying.(2021).Structural Characterization of a Polysaccharide from Gastrodia elata and Its Bioactivity on Gut Microbiota.MOLECULES,26(15),11.
MLA Huo, Jiangyan,et al."Structural Characterization of a Polysaccharide from Gastrodia elata and Its Bioactivity on Gut Microbiota".MOLECULES 26.15(2021):11.

入库方式： OAI收割

来源：上海药物研究所

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