Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C-H activations for modular click chemistry libraries
文献类型：期刊论文
| 作者 | Zhang, Jun1; Wang, Mengmeng2; Wang, Huiying2; Xu, Hui3; Chen, Junjie3; Guo, Ziqiong3; Ma, Biao3; Ban, Shu-Rong1; Dai, Hui-Xiong2,3,4
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| 刊名 | CHEMICAL COMMUNICATIONS
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| 出版日期 | 2021-08-04 |
| 页码 | 4 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/d1cc02798k |
| 通讯作者 | Ma, Biao(bma@simm.ac.cn) ; Ban, Shu-Rong(shurongban@sxmu.edu.cn) ; Dai, Hui-Xiong(hxdai@simm.ac.cn) |
| 英文摘要 | Herein, we have developed a strategy of sequential C-H activations of indole to construct novel 2-alkynyl aza-spiro[4,5]indole scaffolds, which incorporated both alkyne and spiro-units into indole. Gram-scale synthesis and a one-pot, three-step synthesis demonstrated the utility of this protocol. Hybrid conjugates with an oseltamivir derivative further offered a powerful tool for the construction of a versatile spiroindole-containing library via click chemistry. |
| WOS关键词 | IN-SITU ; ALKYNYLATION ; INDOLES ; FUNCTIONALIZATION ; DESIGN ; ACETYLCHOLINESTERASE ; ALKYLATION ; DISCOVERY ; ALKALOIDS ; ACCESS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000683354400001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298168]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ma, Biao; Ban, Shu-Rong; Dai, Hui-Xiong |
| 作者单位 | 1.Shanxi Med Univ, Sch Pharmaceut Sci, 56 Xinjian South Rd, Taiyuan 030001, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China 3.Chinese Acad Sci, Univ Chinese Acad Sci, Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jun,Wang, Mengmeng,Wang, Huiying,et al. Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C-H activations for modular click chemistry libraries[J]. CHEMICAL COMMUNICATIONS,2021:4. |
| APA | Zhang, Jun.,Wang, Mengmeng.,Wang, Huiying.,Xu, Hui.,Chen, Junjie.,...&Dai, Hui-Xiong.(2021).Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C-H activations for modular click chemistry libraries.CHEMICAL COMMUNICATIONS,4. |
| MLA | Zhang, Jun,et al."Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C-H activations for modular click chemistry libraries".CHEMICAL COMMUNICATIONS (2021):4. |
入库方式： OAI收割
来源：上海药物研究所
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