Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
文献类型：期刊论文
| 作者 | Fan, Min1,3; Wang, Ting2; Peng, Li-Yan1; Huang, Jun-Shang2; Wu, Xing-De1; Wang, He-Yao2 ; Zhao, Qin-Shi1
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2021-08-04 |
| 页码 | 6 |
| 关键词 | Salvia hispanica neo-clerodane diterpenoid salvihispin H type 2 diabetes mellitus |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202100517 |
| 通讯作者 | Wu, Xing-De(wuxingde@mail.kib.ac.cn) ; Wang, He-Yao(hywang@simm.ac.cn) ; Zhao, Qin-Shi(qinshizhao@mail.kib.ac.cn) |
| 英文摘要 | A new neo-clerodane diterpenoid, salvihispin H (1), and six known ones (2-7) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic (H-1, C-13, and 2D NMR, and HR-ESI-MS) and single-crystal X-ray diffraction data. The anti-diabetic effects of salvihispin H (1) and salvifaricin (2) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could significantly reduce fasting blood glucose level and improve insulin resistance, and compound 1 exerted glucose-lowering effect more quickly than metformin. In addition, 1 and 2 could also reduce serum TG level in db/db mice. These results demonstrated that compounds 1 and 2 could be considered as potent candidates for the therapy of type 2 diabetes mellitus (T2DM). |
| WOS关键词 | GLUCOSE-TOLERANCE ; RISK-FACTORS ; THERAPY |
| 资助项目 | State Key Laboratory of Phytochemistry and Plant Resources in West China[P2018-KF04] ; National Natural Science Foundation of China[21837003] ; National Natural Science Foundation of China[81773611] ; Science and Technology Program of Yunnan province[2018ZF001] ; Science and Technology Program of Yunnan province[2019FA037] ; Top Young Talent of the Ten Thousand Talents Program of Yunnan Province |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000680807100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298247]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Xing-De; Wang, He-Yao; Zhao, Qin-Shi |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Dali Univ, Coll Pharm, Dali 671000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Min,Wang, Ting,Peng, Li-Yan,et al. Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.[J]. CHEMISTRY & BIODIVERSITY,2021:6. |
| APA | Fan, Min.,Wang, Ting.,Peng, Li-Yan.,Huang, Jun-Shang.,Wu, Xing-De.,...&Zhao, Qin-Shi.(2021).Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L..CHEMISTRY & BIODIVERSITY,6. |
| MLA | Fan, Min,et al."Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.".CHEMISTRY & BIODIVERSITY (2021):6. |
入库方式： OAI收割
来源：上海药物研究所
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