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Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

文献类型：期刊论文

作者Gao, Mengqing1,2,3; Wang, Jin1,3; Rousseaux, Sophie2,3; Tan, Minjia4; Pan, Lulu4; Peng, Lijun1,3; Wang, Sisi1,3; Xu, Wenqian1,3; Ren, Jiayi1,3; Liu, Yuanfang1
刊名CELL REPORTS
出版日期2021-07-27
卷号36期号:4页码:22
ISSN号2211-1247
DOI10.1016/j.celrep.2021.109460
通讯作者Mi, Jian-Qing(jianqingmi@shsmu.edu.cn) ; Khochbin, Saadi(saadi.khochbin@univ-grenoble-alpes.fr)
英文摘要In addition to acetylation, histones are modified by a series of competing longer-chain acylations. Most of these acylation marks are enriched and co-exist with acetylation on active gene regulatory elements. Their seemingly redundant functions hinder our understanding of histone acylations' specific roles. Here, by using an acute lymphoblastic leukemia (ALL) cell model and blasts from individuals with B-precusor ALL (B-ALL), we demonstrate a role of mitochondrial activity in controlling the histone acylation/acetylation ratio, especially at histone H4 lysine 5 (H4K5). An increase in the ratio of non-acetyl acylations (crotonylation or butyrylation) over acetylation on H4K5 weakens bromodomain containing protein 4 (BRD4) bromodomain-dependent chromatin interaction and enhances BRD4 nuclear mobility and availability for binding transcription start site regions of active genes. Our data suggest that the metabolism-driven control of the histone acetylation/longer-chain acylation(s) ratio could be a common mechanism regulating the bromodomain factors' functional genomic distribution.
WOS关键词GENE-EXPRESSION ; CROTONYLATION ; TRANSCRIPTION ; BINDING ; PROPIONYLATION ; BROMODOMAINS ; BUTYRYLATION ; ACETYLATION ; RECOGNITION ; HOMEOSTASIS
资助项目Fondation ARC program[RF20190208471] ; Universite Grenoble Alpes[ANR-15-IDEX-02 LIFE] ; INCa ; IreSP ; Cancer ITMO (Multi-Organisation Thematic Institute) of the French Alliance for Life Sciences and Health (AVIESAN) MIC program ; National Natural Science Foundation of China[81670147] ; clinical research plan of the Shanghai Hospital Development Center[16CR3008A] ; international cooperation projects of the Shanghai Science and Technology Committee[15410710200] ; Shanghai Municipal Education Commission[8201001096] ; China Scholarship Council ; University of Chicago ; Nancy and Leonard Florsheim Family Fund ; NIH[GM135504] ; NIH[DK118266] ; Natural Science Foundation of China[91753203] ; Inserm ; Aix-Marseille Universite ; Max Planck Institute of Molecular Physiology ; ANR Episperm4 program ; SYMER program ; Plan Cancer Pitcher ; GIS IBiSA ; MSD Avenir ERICAN programs ; [ANR-10-INBS-0009-10]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000678096100028
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/298259]  
专题中国科学院上海药物研究所
通讯作者Mi, Jian-Qing; Khochbin, Saadi
作者单位1.Shanghai Jiao Tong Univ, Shanghai Inst Hematol, State Key Lab Med Genom,Sch Med, Natl Res Ctr Translat Med Shanghai,Ruijin Hosp, Shanghai 200025, Peoples R China
2.Univ Grenoble Alpes, CNRS, UMR 5309, INSERM,U1209,Inst Adv Biosci, F-38706 La Tronche, France
3.Pole Franco Chinois Rech Sci Vivant & Genom, Shanghai 200025, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
5.Max Planck Inst Mol Physiol, Dept Struct Biochem, Otto Hahn Str 11, D-44227 Dortmund, Germany
6.Aix Marseille Univ, INSERM, TAGC, TGML, F-13288 Marseille, France
7.Jingjie PTM Biolab Hangzhou, Hangzhou 310018, Peoples R China
8.Shanghai Jiao Tong Univ, Ruijin Hosp, Clin Res Ctr, Sch Med, Shanghai 200025, Peoples R China
9.Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA
推荐引用方式
GB/T 7714		 Gao, Mengqing,Wang, Jin,Rousseaux, Sophie,et al. Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution[J]. CELL REPORTS,2021,36(4):22.
APA Gao, Mengqing.,Wang, Jin.,Rousseaux, Sophie.,Tan, Minjia.,Pan, Lulu.,...&Khochbin, Saadi.(2021).Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution.CELL REPORTS,36(4),22.
MLA Gao, Mengqing,et al."Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution".CELL REPORTS 36.4(2021):22.

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来源：上海药物研究所

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