Iridoid Constituents of Viburnum brachybotryum
文献类型：期刊论文
| 作者 | Rao, Li3; Li, Yao1; He, Qian3; Liu, Yu3; Su, Yu3; You, Yun-Xia3; Fan, Yue3; Lin, Bin4; Zhang, Yi-Nan1; Zhang, Chuan-Rui2,3 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2021-07-23 |
| 卷号 | 84期号:7页码:1915-1923 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.1c00042 |
| 通讯作者 | Zhang, Chuan-Rui(crzhang@cqu.edu.cn) |
| 英文摘要 | Eleven new iridoids, brachybones A-K (1-11), were isolated from the twigs of Viburnum brachybotryum. Their structures including absolute configurations were determined by spectroscopic data analysis and from the electronic circular dichroism (ECD) spectra. All of the compounds 1-11 possess one or two acetoxysenecioate substituents. Furthermore, compounds 5-7 and 11 feature a Cl atom in the molecule, while compounds 9-11 exhibit a cagelike rigid skeleton through an unusual oxo bridge from C-3 to C-8 or C-10. The isolates were evaluated for cytotoxic activity against the HCT-116, A549, and Hela cell lines, and the results showed compounds 10 and 11 to be active against HCT-116 cells. |
| WOS关键词 | VIBSANE-TYPE DITERPENOIDS ; LEAVES ; GLYCOSIDES ; ROOTS |
| 资助项目 | Chongqing Research and Frontier Technology[cstc2020jcyj-msxmX0537] ; State Key Laboratory of Drug Research[SIMM1903KF-14] ; Fundamental Research Funds for the Central Universities[2020CDJ-LHZZ-006] ; Fundamental Research Funds for the Central Universities[2020CDJQY-A078] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000677582700007 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298286]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Chuan-Rui |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Pharm, Jiangsu Key Lab Funct Subst Chinese Med, Nanjing 210023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China 4.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Rao, Li,Li, Yao,He, Qian,et al. Iridoid Constituents of Viburnum brachybotryum[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(7):1915-1923. |
| APA | Rao, Li.,Li, Yao.,He, Qian.,Liu, Yu.,Su, Yu.,...&Zhang, Chuan-Rui.(2021).Iridoid Constituents of Viburnum brachybotryum.JOURNAL OF NATURAL PRODUCTS,84(7),1915-1923. |
| MLA | Rao, Li,et al."Iridoid Constituents of Viburnum brachybotryum".JOURNAL OF NATURAL PRODUCTS 84.7(2021):1915-1923. |
入库方式： OAI收割
来源：上海药物研究所
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