Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids
文献类型：期刊论文
| 作者 | Gao, AR ; Lu, N ; Dai, PF ; Li, T ; Pei, H ; Gao, XL ; Gong, YB ; Wang, YL ; Fan, CH（樊春海） |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 11期号:9页码:3974 |
| ISSN号 | 1530-6984 |
| 英文摘要 | We herein report the design of a novel semiconducting silicon nanowire field-effect transistor (SiNW-FET) biosensor array for ultrasensitive label-free and real-time detection of nucleic acids. Highly responsive SiNWs with narrow sizes and high surface-to-volume-ratios were "top-down" fabricated with a complementary metal oxide semiconductor compatible anisotropic self-stop etching technique. When SiNWs were covalently modified with DNA probes, the nanosensor showed highly sensitive concentration-dependent conductance change in response to specific target DNA sequences. This SiNW-FET nanosensor revealed ultrahigh sensitivity for rapid and reliable detection of 1 fM of target DNA and high specificity single-nucleotide polymorphism discrimination. As a proof-of-concept for multiplex detection with this small-size and mass producible sensor array, we demonstrated simultaneous selective detection of two pathogenic strain virus DNA sequences (H1N1 and H5N1) of avian influenza. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294790200080 |
| 公开日期 | 2013-09-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/12879]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Gao, AR,Lu, N,Dai, PF,et al. Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids[J]. NANO LETTERS,2011,11(9):3974. |
| APA | Gao, AR.,Lu, N.,Dai, PF.,Li, T.,Pei, H.,...&Fan, CH.(2011).Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids.NANO LETTERS,11(9),3974. |
| MLA | Gao, AR,et al."Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids".NANO LETTERS 11.9(2011):3974. |
入库方式： OAI收割
来源：上海应用物理研究所
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