Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90
文献类型：期刊论文
| 作者 | Li, Jian（李健） ; Sun, Lihua（孙丽华） ; Xu, Chunyan（徐春艳） ; Yu, Feng（郁峰） ; Zhou, Huan ; Zhao, Yanlong ; Zhang, Jian ; Cai, Jianhua ; Mao, Cheney ; Tang, Lin（唐琳） ; Xu, Yechun ; He, Jianhua（何建华） |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2012 |
| 卷号 | 44期号:4页码:300 |
| ISSN号 | 1672-9145 |
| 英文摘要 | The activation of molecular chaperone heat-shock protein 90 (Hsp90) is dependent on ATP binding and hydrolysis, which occurs in the N-terminal domains of protein. Here, we have determined three crystal structures of the N-terminal domain of human Hsp90 in native and in complex with ATP and ATP analog, providing a clear view of the catalytic mechanism of ATP hydrolysis by Hsp90. Additionally, the binding of ATP leads the N-terminal domains to be an intermediate state that could be used to partially explain why the isolated N-terminal domain of Hsp90 has very weak ATP hydrolytic activity. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000302297500003 |
| 公开日期 | 2013-09-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/12915]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Li, Jian,Sun, Lihua,Xu, Chunyan,et al. Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2012,44(4):300. |
| APA | Li, Jian.,Sun, Lihua.,Xu, Chunyan.,Yu, Feng.,Zhou, Huan.,...&He, Jianhua.(2012).Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,44(4),300. |
| MLA | Li, Jian,et al."Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 44.4(2012):300. |
入库方式： OAI收割
来源：上海应用物理研究所
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