A study of the radiosynthesis of fac-[Re-188(CO)(3)(H2O)(3)](+) and its application in labeling 1,2,3-triazole analogs obtained by click chemistry
文献类型：期刊论文
| 作者 | Wang, C（王成） ; Zhou, W(周伟） ; Yu, JF（于俊峰） ; Zhang, L（张岚） ; Wang, N（王妮） |
| 刊名 | NUCLEAR MEDICINE COMMUNICATIONS
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:1 |
| ISSN号 | 0143-3636 |
| 英文摘要 | Objectives To optimize the conditions for the preparation of the organometallic precursor fac-[Re-188(CO)(3)(H2O)(3)](+) and to synthesize the radiolabeling compounds of tricarbonyl rhenium. 1,2,3-Triazole analogs were synthesized by click chemistry and labeled with fac[ Re(CO)(3)(H2O)(3)]Br and fac-[Re-188(CO)(3)(H2O)(3)](+). The aim was to improve the methods for the synthesis of 188 Re-labeled radiopharmaceuticals for therapy. Methods With potassium boranocarbonate as the CO source and ammonia borane as the reducing agent, fac-[188 Re(CO) 3(H2O) 3] + was synthesized, and the click chemistry method was used to prepare the tricarbonyl rhenium complex. Results At the optimal reaction condition (the amounts of K-2[H3BCO2] and BH3 center dot NH3 are 5 and 5 mg, respectively; reaction temperature is 75 degrees C; and reaction time is 15 min), the radiochemical yields were 90%, and the labeling yield of bis(pyridin-2-ylmethyl) amine with fac-[Re-188(CO)(3)(H2O)(3)](+) was more than 99% in 1 h at 758C; the conjugation yields of triazole analog obtained by click chemistry with 'cold' and 'radio' tricarbonyl rhenium were more than 80%. Conclusion The organometallic precursor fac-[188 Re(CO) 3(H2O) 3] + was prepared under optimal reaction conditions with a yield of 90%, and the triazole analogs synthesized by click chemistry were suitable ligands for tricarbonyl rhenium. Nucl Med Commun 33:84-89 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. |
| 语种 | 英语 |
| WOS记录号 | WOS:000298850000012 |
| 公开日期 | 2013-09-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13081]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wang, C,Zhou, W,Yu, JF,et al. A study of the radiosynthesis of fac-[Re-188(CO)(3)(H2O)(3)](+) and its application in labeling 1,2,3-triazole analogs obtained by click chemistry[J]. NUCLEAR MEDICINE COMMUNICATIONS,2012,33(1). |
| APA | Wang, C,Zhou, W,Yu, JF,Zhang, L,&Wang, N.(2012).A study of the radiosynthesis of fac-[Re-188(CO)(3)(H2O)(3)](+) and its application in labeling 1,2,3-triazole analogs obtained by click chemistry.NUCLEAR MEDICINE COMMUNICATIONS,33(1). |
| MLA | Wang, C,et al."A study of the radiosynthesis of fac-[Re-188(CO)(3)(H2O)(3)](+) and its application in labeling 1,2,3-triazole analogs obtained by click chemistry".NUCLEAR MEDICINE COMMUNICATIONS 33.1(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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