A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes
文献类型：期刊论文
| 作者 | Wang, ZW ; Zhang, LJ(张立娟） ; Guo, Z（郭智） ; Liu, L ; Ji, J ; Zhang, JN ; Chen, XH ; Liu, BY ; Zhang, J ; Ding, QL ; Wang, XF ; Zhao, W ; Zhu, ZG ; Yu, YY |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:11 |
| ISSN号 | 1932-6203 |
| 英文摘要 | Iron deficiency anemia is an extra-stomach disease experienced in H. pylori carriers. Individuals with type A blood are more prone to suffering from H. pylori infection than other individuals. To clarify the molecular mechanisms underlying H. pylori-associated anemia, we collected erythrocytes from A, B, O, and AB blood donors and analyzed morphology, the number of erythrocytes with H. pylori colonies attached to them, and iron contents in erythrocytes and H. pylori (NCTC11637 and SS1 strains) by means of optical microscopy, scanning electron microscopy, and synchrotron radiation soft X-ray imaging. The number of type A erythrocytes with H. pylori attached to them was significantly higher than that of other erythrocytes (P<0.05). Far more iron distribution was observed in H. pylori bacteria using dual energy analysis near the iron L2, 3 edges by soft X-ray imaging. Iron content was significantly reduced in host erythrocytes after 4 hours of exposure to H. pylori. H. pylori are able to adhere more strongly to type A erythrocytes, and this is related to iron shift from the host to the bacteria. This may explain the reasons for refractory iron deficiency anemia and elevated susceptibility to H. pylori infection in individuals with type A blood. |
| 语种 | 英语 |
| WOS记录号 | WOS:000311821000217 |
| 公开日期 | 2013-09-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13084]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wang, ZW,Zhang, LJ,Guo, Z,et al. A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes[J]. PLOS ONE,2012,7(11). |
| APA | Wang, ZW.,Zhang, LJ.,Guo, Z.,Liu, L.,Ji, J.,...&Yu, YY.(2012).A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes.PLOS ONE,7(11). |
| MLA | Wang, ZW,et al."A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes".PLOS ONE 7.11(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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