Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila
文献类型：期刊论文
| 作者 | Wang, B ; Chen, N（陈楠） ; Wei, YL ; Li, J（李江） ; Sun, L ; Wu, JR ; Huang, Q（黄庆） ; Liu, C ; Fan, CH（樊春海） ; Song, HY |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2012 |
| 卷号 | 2 |
| ISSN号 | 2045-2322 |
| 英文摘要 | Gold nanoparticles (AuNPs) are often used as vehicles to deliver drugs or biomolecules, due to their mild effect on cell survival and proliferation. However, little is known about their effect on cellular metabolism. Here we examine the in vivo effect of AuNPs on metabolism using Drosophila as a model. Drosophila and vertebrates possess similar basic metabolic functions, and a highly conserved PI3K/Akt/mTOR signaling pathway plays a central role in the regulation of energy metabolism in both organisms. We show that dietary AuNPs enter the fat body, a key metabolic tissue in Drosophila larvae. Significantly, larvae fed with AuNP show increased lipid levels without triggering stress responses. In addition, activities of the PI3K/Akt/mTOR signaling pathway and fatty acids synthesis are increased in these larvae. This study thus reveals a novel function of AuNPs in influencing animal metabolism and suggests its potential therapeutic applications for metabolic disorders. |
| 语种 | 英语 |
| WOS记录号 | WOS:000307874600003 |
| 公开日期 | 2013-09-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13087]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wang, B,Chen, N,Wei, YL,et al. Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila[J]. SCIENTIFIC REPORTS,2012,2. |
| APA | Wang, B.,Chen, N.,Wei, YL.,Li, J.,Sun, L.,...&Song, HY.(2012).Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila.SCIENTIFIC REPORTS,2. |
| MLA | Wang, B,et al."Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila".SCIENTIFIC REPORTS 2(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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