Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats
文献类型：期刊论文
| 作者 | Chen, X ; Zhu, GY ; Jin, TY ; Shao, CL ; Gu, SZ ; Tan, MG（谈明光） ; Zhang, YY ; Xiao, HF ; Hu, HP ; Yu, YZ |
| 刊名 | ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 62期号:1 |
| ISSN号 | 0090-4341 |
| 英文摘要 | This study investigated bone status after decreased cadmium (Cd) exposure in male rats. Sprague-Dawley male rats were randomly divided into three groups. One group was injected subcutaneously with sodium chloride as control. The others were given CdCl(2) by subcutaneous injection at doses of 0.5 mg Cd/kg body weight (bw) for 2 months (Cd+2m) and for 3 months (Cd+3m). For the Cd+2m group, the rats were shifted to cessation of Cd injection for 1 month after 2 months' exposure. At month 3, micro-computed tomography (micro-CT) analyses were performed on the proximal tibia and lumbar spine, and urine was collected from all rats. Rats were then killed and blood collected for metabolic-marker measurement and Cd assay. Bone tissues were also collected for bone-mass assay, biomechanical test, and bone-histology analysis. Cd burdens of rats in the Cd+2m and Cd+3m groups were both significantly greater than those in the control group. Cd burdens of rats were lower in the Cd+2m group compared with the Cd+3m group. Bone damage occurred in the Cd+2m and Cd+3m groups compared with the control group (p < 0.05), but no significant improvement was found in the Cd+2m group compared with the Cd+3m group. Cd damage to bone could not be reversed over the short term. More attention should be paid to Cd's toxic effects on bone after decreased exposure. |
| 语种 | 英语 |
| WOS记录号 | WOS:000298501600019 |
| 公开日期 | 2013-09-11 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/13099]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Chen, X,Zhu, GY,Jin, TY,et al. Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats[J]. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2012,62(1). |
| APA | Chen, X.,Zhu, GY.,Jin, TY.,Shao, CL.,Gu, SZ.,...&Yu, YZ.(2012).Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats.ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,62(1). |
| MLA | Chen, X,et al."Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats".ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 62.1(2012). |
入库方式： OAI收割
来源：上海应用物理研究所
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