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Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules

文献类型：期刊论文

作者Geng, Rui2; Chang, Rui1; Zou, Qianli1,3; Shen, Guizhi1,4; Jiao, Tifeng2; Yan, Xuehai1
刊名SMALL
出版日期2021-03-24
页码6
关键词amino acid hemin nanozymes peroxidase self‐ assembly
ISSN号1613-6810
DOI10.1002/smll.202008114
英文摘要Nanoassemblies based on self-assembly of biological building blocks are promising in mimicking the nanostructures, properties, and functionalities of natural enzymes. However, it remains a challenge to design of biomimetic nanozymes with tunable nanostructures and enhanced catalytic activities starting from simple biomolecules. Herein, the construction of nanoassemblies through coassembly of an amphiphilic amino acid and hemin is reported. The nanostructures and morphologies of the resulting nanoassemblies are readily controlled by tuning the molar ratio between the amino acid and hemin, thus leading to tailored peroxidase-mimicking activities of the nanoassemblies. Importantly, the optimized nanoassemblies exhibit a remarkable catalytic efficiency that is comparable to the natural counterpart when considering molecular mass along with good robustness in multiple catalytic cycles. The nanoassemblies are effectively integrated as biomimetic nanozymes in a sensing system for catalytic detection of glucose. Therefore, this work demonstrates that nanozymes with advanced catalytic capabilities can be constructed by self-assembly of minimalist biological building blocks and may thus promote the rational design and catalytic applications of biomimetic nanozymes.
资助项目National Natural Science Foundation of China[22025207] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Key Research Program of Nanjing IPE Institute of Green Manufacturing Industry[E0010722]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000631980200001
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Key Research Program of Nanjing IPE Institute of Green Manufacturing Industry
源URL[http://ir.ipe.ac.cn/handle/122111/47975]  
专题中国科学院过程工程研究所
通讯作者Zou, Qianli; Jiao, Tifeng; Yan, Xuehai
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China
3.Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
4.Nanjing IPE Inst Green Mfg Ind, Nanjing 211135, Peoples R China
推荐引用方式
GB/T 7714		 Geng, Rui,Chang, Rui,Zou, Qianli,et al. Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules[J]. SMALL,2021:6.
APA Geng, Rui,Chang, Rui,Zou, Qianli,Shen, Guizhi,Jiao, Tifeng,&Yan, Xuehai.(2021).Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules.SMALL,6.
MLA Geng, Rui,et al."Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules".SMALL (2021):6.

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来源：过程工程研究所

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