Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer
文献类型：期刊论文
| 作者 | Lv, Yanlin1,3; Li, Feng3,4; Wang, Shuang3; Lu, Guihong3; Bao, Weier1; Wang, Yugang2; Tian, Zhiyuan1; Wei, Wei3,4; Ma, Guanghui3,4 |
| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2021-03-01 |
| 卷号 | 7期号:13页码:16 |
| ISSN号 | 2375-2548 |
| DOI | 10.1126/sciadv.abd7614 |
| 英文摘要 | To address long-standing issues with tumor penetration and targeting among cancer therapeutics, we developed an anticancer platelet-based biomimetic formulation (N+R@PLTs), integrating photothermal nanoparticles (N) and immunostimulator (R) into platelets (PLTs). Exploiting the aggregative properties of platelets and high photothermal capacity, N+R@PLTs functioned as an arsenal by targeting defective tumor vascular endothelial cells, accumulating in a positive feedback aggregation cascade at sites of acute vascular damage induced by N-generated local hyperthermia, and subsequently secreting nanosized proplatelets (nPLTs) to transport active components to deep tumor tissue. The immunostimulator augmented the immunogenicity of antigens released from ablated tumors, inducing a stronger immunological response to attack residual, metastatic, and recurrent tumors. Following activation by low-power near-infrared light irradiation, the photothermal and immunological components synergistically provide exceptionally high therapeutic efficacy across nine murine models that mimicked a range of clinical requirements, and, most notably, a sophisticated model based on humanized mouse and patient-derived tumor xenograft. |
| 资助项目 | National Natural Science Foundation of China[21773241] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[21907096] ; National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| WOS记录号 | WOS:000633443600010 |
| 资助机构 | National Natural Science Foundation of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/48066]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Tian, Zhiyuan; Wei, Wei; Ma, Guanghui |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Tongren Hosp, Sch Med, Dept Gastroenterol, Shanghai 200336, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Yanlin,Li, Feng,Wang, Shuang,et al. Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer[J]. SCIENCE ADVANCES,2021,7(13):16. |
| APA | Lv, Yanlin.,Li, Feng.,Wang, Shuang.,Lu, Guihong.,Bao, Weier.,...&Ma, Guanghui.(2021).Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer.SCIENCE ADVANCES,7(13),16. |
| MLA | Lv, Yanlin,et al."Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer".SCIENCE ADVANCES 7.13(2021):16. |
入库方式： OAI收割
来源：过程工程研究所
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