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Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy

文献类型：期刊论文

作者Li, Shukun2,3; Zhang, Wenjia1; Xing, Ruirui3; Yuan, Chengqian3; Xue, Huadan1; Yan, Xuehai2,3
刊名ADVANCED MATERIALS
出版日期2021-04-19
页码9
关键词cancer peptides photosensitizers photothermal immunotherapy self‐ assembly
ISSN号0935-9648
DOI10.1002/adma.202100595
英文摘要Pancreatic cancer, one of the most lethal malignancies, compromises the performance of traditional therapeutic regimens in the clinic because of stromal resistance to systemic drug delivery and poor prognosis caused by tumor metastasis. Therefore, a biocompatible therapeutic paradigm that can effectively inhibit pancreatic tumor growth while simultaneously eliminating tumor metastasis is urgently needed. Herein, supramolecular nanofibrils are fabricated through coassembly of clinically approved immunomodulatory thymopentin and near-infrared indocyanine green for localized photothermal immunotherapy of pancreatic tumors. The resulting long-range ordered fibrous nanodrugs show improved photophysical capabilities for fluorescence imaging and photothermal conversion and significantly promote the proliferation and differentiation of antitumor immune cells. Hence, the integration of rapid photothermal therapy and moderate immunomodulation for inhibiting tumor growth and eliminating tumor metastasis is promising. The utilization of clinically approved molecules to construct nanodrugs administered via localized injection amplifies the complementary photothermal immunotherapeutic effects of the components, creating opportunities for clinical translation as a treatment for pancreatic cancer.
资助项目National Science Fund for Distinguished Young Scholars of China[22025207] ; National Natural Science Foundation of China[22072154] ; National Natural Science Fund BRICS STI Framework Program of China[51861145304] ; Innovation Research Community Science Fund of China[21821005] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000641165700001
出版者WILEY-V C H VERLAG GMBH
资助机构National Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Program of China ; Innovation Research Community Science Fund of China ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)
源URL[http://ir.ipe.ac.cn/handle/122111/48251]  
专题中国科学院过程工程研究所
通讯作者Xing, Ruirui; Xue, Huadan; Yan, Xuehai
作者单位1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
2.Peking Union Med Coll Hosp, Dept Radiol, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Li, Shukun,Zhang, Wenjia,Xing, Ruirui,et al. Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy[J]. ADVANCED MATERIALS,2021:9.
APA Li, Shukun,Zhang, Wenjia,Xing, Ruirui,Yuan, Chengqian,Xue, Huadan,&Yan, Xuehai.(2021).Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy.ADVANCED MATERIALS,9.
MLA Li, Shukun,et al."Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy".ADVANCED MATERIALS (2021):9.

入库方式： OAI收割

来源：过程工程研究所

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