Metal-Free Nanoassemblies of Water-Soluble Photosensitizer and Adenosine Triphosphate for Efficient and Precise Photodynamic Cancer Therapy
文献类型：期刊论文
| 作者 | Li, Zhiliang1,2; Li, Shukun3,4; Guo, Yanhui1; Yuan, Chengqian3; Yan, Xuehai3,4; Schanze, Kirk S.2 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2021-03-23 |
| 卷号 | 15期号:3页码:4979-4988 |
| 关键词 | photodynamic therapy self-assembly tumor microenvironment nanodrugs adenosine triphosphate |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.0c09913 |
| 英文摘要 | Engineering photosensitizers into stimuli-responsive supramolecular nanodrugs allows enhanced spatiotemporal delivery and controllable release of photosensitizers, which is promising for dedicated and precise tumor photodynamic therapy. Complicated fabrication for nanodrugs with good tumor accumulation capability and the undesirable side-effects caused by the drug components retards the application of PDT in vivo. The fact that extracellular adenosine triphosphate (ATP) is overexpressed in tumor tissue has been overlooked in fabricating nanomedicines for tumor-targeting delivery. Hence, herein we present metal-free helical nanofibers formed in aqueous solution from the coassembly of a cationic porphyrin and ATP as a nanodrug for PDT. The easily accessible and compatible materials and simple preparation enable the nanodrugs with potential in PDT for cancer. Compared to the cationic porphyrin alone, the porphyrin-ATP nanofibers exhibited enhanced tumor-site photosensitizer delivery through whole-body blood circulation. Overexpressed extracellular ATP stabilizes the porphyrin-ATP nanodrug within tumor tissue, giving rise to enhanced uptake of the nanodrug by cancer cells. The enzyme-triggered release of photosensitizers from the nanodrugs upon biodegradation of ATP by intracellular phosphatases results in good tumor therapeutic efficacy. This study demonstrates the potential for employing the tumor microenvironment to aid the accumulation of nanodrugs in tumors, inspiring the fabrication of smart nanomedicines. |
| 资助项目 | Welch Foundation through Welch Chair at the University of Texas at San Antonio[AX-0045-20110629] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000634569100107 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | Welch Foundation through Welch Chair at the University of Texas at San Antonio ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/48255]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yan, Xuehai; Schanze, Kirk S. |
| 作者单位 | 1.Shandong Univ, Inst Mol Sci & Engn, Inst Frontier & Interdisciplinary Sci, Qingdao 266237, Shandong, Peoples R China 2.Univ Texas San Antonio, Dept Chem, San Antonio, TX 78249 USA 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhiliang,Li, Shukun,Guo, Yanhui,et al. Metal-Free Nanoassemblies of Water-Soluble Photosensitizer and Adenosine Triphosphate for Efficient and Precise Photodynamic Cancer Therapy[J]. ACS NANO,2021,15(3):4979-4988. |
| APA | Li, Zhiliang,Li, Shukun,Guo, Yanhui,Yuan, Chengqian,Yan, Xuehai,&Schanze, Kirk S..(2021).Metal-Free Nanoassemblies of Water-Soluble Photosensitizer and Adenosine Triphosphate for Efficient and Precise Photodynamic Cancer Therapy.ACS NANO,15(3),4979-4988. |
| MLA | Li, Zhiliang,et al."Metal-Free Nanoassemblies of Water-Soluble Photosensitizer and Adenosine Triphosphate for Efficient and Precise Photodynamic Cancer Therapy".ACS NANO 15.3(2021):4979-4988. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。