Predictive Value of Folate Receptor-Positive Circulating Tumor Cells for the Preoperative Diagnosis of Lymph Node Metastasis in Patients with Lung Adenocarcinoma
文献类型：期刊论文
| 作者 | Li, Zhao4; Xu, Ke1; Xu, Lekai3; Dai, Jie4; Jin, Kaiqi4; Zhu, Yuming4; Yang, Yang2,4; Jiang, Gening4 |
| 刊名 | SMALL METHODS
 |
| 出版日期 | 2021-04-10 |
| 页码 | 9 |
| 关键词 | folate receptor-positive circulating tumor cells lymph node metastasis non-small cell lung cancer prediction models |
| ISSN号 | 2366-9608 |
| DOI | 10.1002/smtd.202100152 |
| 英文摘要 | Noninvasive assessments of the risk of lymph node metastasis (LNM) in patients with lung adenocarcinoma (LAD) are of great value for selecting individualized treatment options. However, the diagnostic accuracies of different preoperative LN evaluation methods in routine clinical practice are not satisfactory. Here, an assessment to detect folate receptor (FR)-positive circulating tumor cells (CTCs) based on ligand-targeted enzyme-linked polymerization is established. FR-positive CTCs have the potential to improve the specificity and sensitivity of diagnosing LNM in lung cancer patients. The addition of CTC level improved the diagnostic efficiency of the initial prediction model that comprises other clinical parameters. A nomogram for predicting preoperative LNM is established, which showed good prediction and calibration capacities and achieved an average area under the curve of 0.786. Good correlations are observed between the CTC level and nodal classifications, such as the number of positive LNs and the ratio of the number of positive LNs to removed LNs (LN ratio or LNR). The ligand-targeted enzyme-linked polymerization-assisted assessment of CTCs enables noninvasive detection and has a useful predictive value for the preoperative diagnosis of LNM in patients with LAD. |
| 资助项目 | National Natural Science Foundation of China (NSFC)[51872205] ; National Natural Science Foundation of China (NSFC)[51922077] ; National Program on Key Basic Research Project of China (Youth 973 Program)[2020YFA0211100] ; Cultivation Project of Shanghai Pulmonary Hospital[Fkcx1905] ; Cultivation Project of Shanghai Pulmonary Hospital[fk1911] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000638541200001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China (NSFC) ; National Program on Key Basic Research Project of China (Youth 973 Program) ; Cultivation Project of Shanghai Pulmonary Hospital |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/48302]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhu, Yuming; Yang, Yang; Jiang, Gening |
| 作者单位 | 1.Guangzhou Med Univ, Affiliated Hosp 1, Dept Thorac Surg, 151 Yanjiang Rd, Guangzhou 510120, Peoples R China 2.Tongji Univ, Sch Mat Sci & Engn, Shanghai 201804, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Beiertiao, Beijing 100109, Peoples R China 4.Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Thorac Surg, 507 Zhengmin Rd, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhao,Xu, Ke,Xu, Lekai,et al. Predictive Value of Folate Receptor-Positive Circulating Tumor Cells for the Preoperative Diagnosis of Lymph Node Metastasis in Patients with Lung Adenocarcinoma[J]. SMALL METHODS,2021:9. |
| APA | Li, Zhao.,Xu, Ke.,Xu, Lekai.,Dai, Jie.,Jin, Kaiqi.,...&Jiang, Gening.(2021).Predictive Value of Folate Receptor-Positive Circulating Tumor Cells for the Preoperative Diagnosis of Lymph Node Metastasis in Patients with Lung Adenocarcinoma.SMALL METHODS,9. |
| MLA | Li, Zhao,et al."Predictive Value of Folate Receptor-Positive Circulating Tumor Cells for the Preoperative Diagnosis of Lymph Node Metastasis in Patients with Lung Adenocarcinoma".SMALL METHODS (2021):9. |
入库方式： OAI收割
来源：过程工程研究所
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