Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo
文献类型：期刊论文
| 作者 | Wang, Yujie1,3; Wen, Rong1,2; Liu, Dongdong1; Zhang, Chen1; Wang, Zhuo A.1; Du, Yuguang1 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2021-04-01 |
| 卷号 | 26期号:8页码:16 |
| 关键词 | chitosan oligosaccharide intestinal barrier mucus intestinal tight junction inflammatory bowel disease |
| DOI | 10.3390/molecules26082199 |
| 英文摘要 | Intestinal barrier dysfunction is an essential pathological change in inflammatory bowel disease (IBD). The mucus layer and the intestinal epithelial tight junction act together to maintain barrier integrity. Studies showed that chitosan oligosaccharide (COS) had a positive effect on gut health, effectively protecting the intestinal barrier in IBD. However, these studies usually focused on its impact on the intestinal epithelial tight junction. The influence of COS on the intestinal mucus layer is still poorly understood. In this study, we explored the effect of COS on intestinal mucus in vitro using human colonic mucus-secreted HT-29 cells. COS relieved DSS (dextran sulfate sodium)-induced mucus defects. Additionally, the structural characteristics of COS greatly influenced this activity. Finally, we evaluated the protective effect of COS on intestinal barrier function in mice with DSS-induced colitis. The results indicated that COS could manipulate intestinal mucus production, which likely contributed to its intestinal protective effects. |
| 资助项目 | National Key Research and Development Program of China[2019YFD0902000] ; National Natural Science Foundation of China[31870802] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000644618500001 |
| 出版者 | MDPI |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/48479]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wang, Zhuo A.; Du, Yuguang |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Sichuan Normal Univ, Coll Life Sci, Chengdu 610101, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yujie,Wen, Rong,Liu, Dongdong,et al. Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo[J]. MOLECULES,2021,26(8):16. |
| APA | Wang, Yujie,Wen, Rong,Liu, Dongdong,Zhang, Chen,Wang, Zhuo A.,&Du, Yuguang.(2021).Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo.MOLECULES,26(8),16. |
| MLA | Wang, Yujie,et al."Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo".MOLECULES 26.8(2021):16. |
入库方式： OAI收割
来源：过程工程研究所
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