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Fractionated regimen-suitable immunoradiotherapy sensitizer based on ultrasmall Fe4Se2W18 nanoclusters enable tumor-specific radiosensitization augment and antitumor immunity boost

文献类型：期刊论文

作者Zhou, Ruyi4,5,6; Yan, Liang4,5; Dong, Xinghua4,5,6; Zhu, Shuang4,5; Chen, Kui4,5; Wu, Yuanzheng4,5; Xiang, Huandong4,5; Li, Lele2; Zhang, Guangjin3; Gu, Zhanjun4,5,6
刊名NANO TODAY
出版日期2021-02-01
卷号36页码:13
ISSN号1748-0132
关键词Immunoradiotherapy Abscopal effect Fractionated regimen Sandwich-type polyoxotungstate Fenton reaction Oxidative stress
DOI10.1016/j.nantod.2020.101003
英文摘要Immunoradiotherapy involving the combination of spatial control of radiotherapy and systemic survival of immunotherapy together has emerged as a promising strategy for both local and systemic tumor rejection. However, immunoradiotherapeutic efficacy is highly impeded by the radiation-induced immunosuppression and the insufficiency of antitumor immunity. Herein, ultrasmall Sandwich-type polyoxotungstate nanoclusters (Fe4Se2W18 NCs) with abundant high Z elements, efficient catalytic property, and unique electron structure are designed as the immunoradio-sensitizers. Apart from enhancing X-ray deposition for dose reduction, Fe4Se2W18 NCs exhibit tumor microenvironment-responsive catalytic activity, mainly through GSH depletion and Fenton reaction. Upon X-ray irradiation, Fe4Se2W18 NCs generate hydroxyl radical cascade to elevate tumor-specific oxidative stress, which can not only selectively ablate the local tumor but also effectively activate antitumor immune response. More importantly, ultrasmall Fe4Se2W18 NCs can be rapidly eliminated from the body, which can satisfy the needs of the fractionated regimen of radiotherapy clinically to reduce radiation-induced immunosuppression. Immune checkpoint inhibitor (anti-PD-Ll antibody) is further introduced into this system to boost a robust antitumor immunity, resulting in the inhibition of both primary and distant tumors. By presenting the Sandwich-type polyoxotungstate nanoclusters for immunoradiotherapy augmentation, this study is anticipated to establish a novel paradigm for immunoradio-sensitizer design based on polyoxometalate nanoclusters. (C) 2020 Elsevier Ltd. All rights reserved.
资助项目Strategic Priority Research Program of Chinese Academy of Sciences[XDB36000000] ; National Basic Research Program of China[2016YFA0201600] ; National Natural Science Foundation of China[51822207] ; National Natural Science Foundation of China[51772292] ; National Natural Science Foundation of China[11621505] ; National Natural Science Foundation of China[31700866] ; Youth Innovation Promotion Association CAS[2013007] ; Innovation Program of the Chinese Academy of Science[QYZDJ-SSW-SLH022]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000637808000002
资助机构Strategic Priority Research Program of Chinese Academy of Sciences ; National Basic Research Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Innovation Program of the Chinese Academy of Science
源URL[http://ir.ipe.ac.cn/handle/122111/48488]  
专题中国科学院过程工程研究所
通讯作者Gu, Zhanjun
作者单位1.GBA Res Innovat Inst Nanotechnol, Shenzhen 510700, Guangdong, Peoples R China
2.Chinese Acad Sci, Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100049, Peoples R China
6.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Ruyi,Yan, Liang,Dong, Xinghua,et al. Fractionated regimen-suitable immunoradiotherapy sensitizer based on ultrasmall Fe4Se2W18 nanoclusters enable tumor-specific radiosensitization augment and antitumor immunity boost[J]. NANO TODAY,2021,36:13.
APA Zhou, Ruyi.,Yan, Liang.,Dong, Xinghua.,Zhu, Shuang.,Chen, Kui.,...&Zhao, Yuliang.(2021).Fractionated regimen-suitable immunoradiotherapy sensitizer based on ultrasmall Fe4Se2W18 nanoclusters enable tumor-specific radiosensitization augment and antitumor immunity boost.NANO TODAY,36,13.
MLA Zhou, Ruyi,et al."Fractionated regimen-suitable immunoradiotherapy sensitizer based on ultrasmall Fe4Se2W18 nanoclusters enable tumor-specific radiosensitization augment and antitumor immunity boost".NANO TODAY 36(2021):13.

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来源：过程工程研究所

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