Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies
文献类型：期刊论文
| 作者 | Ji, Weihong1,2; Li, Yan1; Liu, Ruiyuan1,2; Lu, Zhiguo1,2; Liu, Linying1,2; Shi, Zhuyan1,2; Shen, Jie1,2; Zhang, Xin1 |
| 刊名 | MATERIALS HORIZONS
 |
| 出版日期 | 2021-04-01 |
| 卷号 | 8期号:4页码:1199-1206 |
| ISSN号 | 2051-6347 |
| DOI | 10.1039/d0mh01542c |
| 英文摘要 | Synaptic vesicle-inspired nanoparticles (RT-PPB NPs) as a "nanoguard'' were designed for clearing the toxic a-synuclein aggregates in diseased neurons and preventing the culprits from escaping to affect other normal cells. The NPs could overcome a series of tissue and cellular barriers and controllably release drugs in the diseased neurons, which ensured the optimization of synergistic treatment. This study indicates that the synaptic vesicle-inspired NPs may have the potential to open up a new avenue for the treatment of synucleinopathies, as well as other neurodegenerative diseases. |
| 资助项目 | Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; Beijing Nova Program[Z201100006820140] |
| WOS研究方向 | Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000639328100022 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | Beijing Natural Science Foundation ; National High Technology Research and Development Program ; National Natural Science Foundation of China ; Beijing Nova Program |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/48544]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhang, Xin |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Weihong,Li, Yan,Liu, Ruiyuan,et al. Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies[J]. MATERIALS HORIZONS,2021,8(4):1199-1206. |
| APA | Ji, Weihong.,Li, Yan.,Liu, Ruiyuan.,Lu, Zhiguo.,Liu, Linying.,...&Zhang, Xin.(2021).Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies.MATERIALS HORIZONS,8(4),1199-1206. |
| MLA | Ji, Weihong,et al."Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies".MATERIALS HORIZONS 8.4(2021):1199-1206. |
入库方式： OAI收割
来源：过程工程研究所
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