The potential of ionic liquids in biopharmaceutical engineering
文献类型：期刊论文
| 作者 | Lin, Xuan; Su, Zhiguo; Yang, Yanli; Zhang, Songping |
| 刊名 | CHINESE JOURNAL OF CHEMICAL ENGINEERING
 |
| 出版日期 | 2021-02-01 |
| 卷号 | 30页码:236-243 |
| 关键词 | Ionic liquids Biopharmaceutical engineering Biomacromolecules Stabilization Vaccine Delivery |
| ISSN号 | 1004-9541 |
| DOI | 10.1016/j.cjche.2020.11.015 |
| 英文摘要 | Biopharmaceuticals, such as proteins, peptides, nucleic acids and vaccines, bring about great hopes for the prevention and treatment of various diseases, but the industrialization of these products still faces challenges such as structural instability, inefficient bioactivity and low bioavailability. Ionic liquids (ILs), the marvelous solvent media with inimitable and tunable properties, may provide alternative solutions to overcome the above problems of biopharmaceutical industry. Progress has gradually been made through studies by combination of ILs with biomacromolecules. The applications involved the stabilization, protection, and delivery of biopharmaceuticals. Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs. However, challenges remain on the toxicity and safety issues. Besides, the cost of adding ILs to the benefits of biopharmaceuticals need to be considered. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved. |
| WOS关键词 | CONFORMATIONAL STABILITY ; CHEMICAL-STABILITY ; PROTEIN STABILITY ; ACUTE TOXICITY ; DELIVERY ; VACCINE ; DRUG ; INSULIN ; STABILIZATION ; DNA |
| 资助项目 | National Natural Science Foundation of China[21808226] ; National Natural Science Foundation of China[31970872] ; National Natural Science Foundation of China[21821005] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000651052100024 |
| 出版者 | CHEMICAL INDUSTRY PRESS CO LTD |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/48985]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yang, Yanli; Zhang, Songping |
| 作者单位 | Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Xuan,Su, Zhiguo,Yang, Yanli,et al. The potential of ionic liquids in biopharmaceutical engineering[J]. CHINESE JOURNAL OF CHEMICAL ENGINEERING,2021,30:236-243. |
| APA | Lin, Xuan,Su, Zhiguo,Yang, Yanli,&Zhang, Songping.(2021).The potential of ionic liquids in biopharmaceutical engineering.CHINESE JOURNAL OF CHEMICAL ENGINEERING,30,236-243. |
| MLA | Lin, Xuan,et al."The potential of ionic liquids in biopharmaceutical engineering".CHINESE JOURNAL OF CHEMICAL ENGINEERING 30(2021):236-243. |
入库方式： OAI收割
来源：过程工程研究所
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