Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes
文献类型：期刊论文
| 作者 | Ma, Shuang-Shuang1,2; Jiang, Biao-Ling1; Yu, Zheng-Kun3; Zhang, Suo-Jiang1,2; Xu, Bao-Hua1,2,3 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021-05-21 |
| 卷号 | 23期号:10页码:3873-3878 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c00992 |
| 英文摘要 | The ligand-free Co-catalyzed chemoselective reductive cyclization cascade of enone-tethered aldehydes with i-PrOH as the environmentally benign hydrogen surrogate is developed by this study. Mechanistic studies disclosed that such a protocol is initiated by an ortho-enone-assisted Co(I)-catalyzed reduction of the aldehyde functionality with i-PrOH. Meanwhile, the selectivity from the Michael-Aldol cycloreduction cascade to the oxa-Michael cascade is feasible and readily adjusted by the addition of steric Lewis bases, such as TEMPO and DABCO, delivering substituted 1H-indenes and dihydroisobenzofurans, respectively. |
| WOS关键词 | C=O |
| 资助项目 | Excellent Young Scientists Fund[22022815] ; Innovation Academy for Green Manufacture, CAS[IAGM2020C13] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000656057300015 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | Excellent Young Scientists Fund ; Innovation Academy for Green Manufacture, CAS |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/49110]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Xu, Bao-Hua |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Shuang-Shuang,Jiang, Biao-Ling,Yu, Zheng-Kun,et al. Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes[J]. ORGANIC LETTERS,2021,23(10):3873-3878. |
| APA | Ma, Shuang-Shuang,Jiang, Biao-Ling,Yu, Zheng-Kun,Zhang, Suo-Jiang,&Xu, Bao-Hua.(2021).Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes.ORGANIC LETTERS,23(10),3873-3878. |
| MLA | Ma, Shuang-Shuang,et al."Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes".ORGANIC LETTERS 23.10(2021):3873-3878. |
入库方式： OAI收割
来源：过程工程研究所
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