Efficient co-production of propionic acid and succinic acid by Propionibacterium acidipropionici using membrane separation coupled technology
文献类型：期刊论文
| 作者 | Li, Xiaolian; Wei, Liquan; Wang, Ziqiang; Wang, Yunshan; Su, Zhiguo |
| 刊名 | ENGINEERING IN LIFE SCIENCES
 |
| 出版日期 | 2021-06-01 |
| 卷号 | 21期号:6页码:429-437 |
| ISSN号 | 1618-0240 |
| 关键词 | combination of glucose and glycerol membrane separation coupled fermentation Propionibacterium acidipropionici propionic acid succinic acid |
| DOI | 10.1002/elsc.202000103 |
| 英文摘要 | To improve the fermentation efficiency of Propionibacterium acidipropionici, a semi-continuous coupled fermentation process was established to achieve co-production of propionic acid (PA) and succinic acid (SA). First, the optimal proportion of glucose (Glc) and glycerol (Gl) as a mixed carbon source was determined, and the feeding procedure of Gl was optimized to make more energy flow in the direction of product synthesis. Then, ZGD630 anion exchange resin was used for efficient adsorption of PA, thereby eliminating the feedback inhibition effect of PA. Finally, an efficient, coupled fermentation process of P. acidipropionici characterized by membrane separation and chromatography technology was developed. The concentrations of PA and SA reached 62.22 +/- 2.32 and 20.45 +/- 1.34 g L-1, with corresponding productivity of 0.43 and 0.14 g L-1 h(-1), increased by 65.38% and 48.54%, respectively. Membrane separation coupled fermentation of PA and SA could significantly improve the process economics of P. acidipropionici, and has good prospects for industrial application. |
| WOS关键词 | IMMOBILIZED CELLS ; CRUDE GLYCEROL ; FERMENTATION ; SHERMANII ; LACTOSE |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000658285000009 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/49134]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wang, Ziqiang |
| 作者单位 | Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, 1 North 2nd St, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaolian,Wei, Liquan,Wang, Ziqiang,et al. Efficient co-production of propionic acid and succinic acid by Propionibacterium acidipropionici using membrane separation coupled technology[J]. ENGINEERING IN LIFE SCIENCES,2021,21(6):429-437. |
| APA | Li, Xiaolian,Wei, Liquan,Wang, Ziqiang,Wang, Yunshan,&Su, Zhiguo.(2021).Efficient co-production of propionic acid and succinic acid by Propionibacterium acidipropionici using membrane separation coupled technology.ENGINEERING IN LIFE SCIENCES,21(6),429-437. |
| MLA | Li, Xiaolian,et al."Efficient co-production of propionic acid and succinic acid by Propionibacterium acidipropionici using membrane separation coupled technology".ENGINEERING IN LIFE SCIENCES 21.6(2021):429-437. |
入库方式： OAI收割
来源：过程工程研究所
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