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Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells

文献类型：期刊论文

作者Tian, Ying6,7; Zhang, Fan5,6; Qiu, Yefeng4; Wang, Shuang6; Li, Feng3,6; Zhao, Jiawei6; Pan, Chao2; Tao, Yong7; Yu, Di1; Wei, Wei3,6
刊名NATURE BIOMEDICAL ENGINEERING
出版日期2021-07-26
页码19
ISSN号2157-846X
DOI10.1038/s41551-021-00764-3
英文摘要Intravitreally injected exosomes derived from regulatory T cells and conjugated with an antibody for vascular endothelial growth factor via a cleavable linker markedly suppress ocular neovascularization in mice and non-human primates. Choroidal neovascularization induced by age-related macular degeneration and retinal neovascularization induced by diabetic retinopathy-two leading causes of blindness-are often treated using antibodies targeting vascular endothelial growth factor (VEGF). Here we report a strong association between inflammation and high VEGF expression in aqueous humour samples from patients with choroidal or retinal neovascularization, and show that intravitreally injected exosomes derived from regulatory T cells and conjugated with an anti-VEGF antibody via a peptide linker that is cleavable by matrix metalloproteinases markedly suppressed ocular neovascularization in mouse and non-human primate models of choroidal neovascularization. The engineered exosomes, which selectively accumulate in the neovascularization lesions, could be adapted for other combination therapies of therapeutic antibodies and anti-inflammatory cargo.
WOS关键词MACULAR DEGENERATION ; INFLAMMATORY CYTOKINES ; INTRAVITREAL DEXAMETHASONE ; AQUEOUS-HUMOR ; BEVACIZUMAB ; RANIBIZUMAB ; MODELS ; NAIVE
资助项目National Natural Science Foundation of China[82070948] ; National Natural Science Foundation of China[U2001224] ; Beijing Chaoyang 1351 talent training programme[CYXX-2017-21] ; Scientific Research Program of Beijing Municipal Commission of Education[KM202010025020]
WOS研究方向Engineering
语种英语
出版者NATURE RESEARCH
WOS记录号WOS:000677707300002
资助机构National Natural Science Foundation of China ; Beijing Chaoyang 1351 talent training programme ; Scientific Research Program of Beijing Municipal Commission of Education
源URL[http://ir.ipe.ac.cn/handle/122111/49522]  
专题中国科学院过程工程研究所
通讯作者Tao, Yong; Yu, Di; Wei, Wei
作者单位1.Univ Queensland, Fac Med, Diamantina Inst, Brisbane, Qld, Australia
2.Beijing Inst Biotechnol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing, Peoples R China
4.Acad Mil Med Sci, Anim Ctr, Beijing, Peoples R China
5.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen, Peoples R China
6.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
7.Capital Med Univ, Beijing Chaoyang Hosp, Dept Ophthalmol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Tian, Ying,Zhang, Fan,Qiu, Yefeng,et al. Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells[J]. NATURE BIOMEDICAL ENGINEERING,2021:19.
APA Tian, Ying.,Zhang, Fan.,Qiu, Yefeng.,Wang, Shuang.,Li, Feng.,...&Wei, Wei.(2021).Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells.NATURE BIOMEDICAL ENGINEERING,19.
MLA Tian, Ying,et al."Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells".NATURE BIOMEDICAL ENGINEERING (2021):19.

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来源：过程工程研究所

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