Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics
文献类型：期刊论文
| 作者 | Li, Xiaozhen7,8; Zhang, Di5,6; Lu, Guihong4; He, Tingchao3; Wan, Yingpeng7,8; Tse, Man-Kit6; Ren, Can3; Wang, Pengfei2,7; Li, Shengliang1,8; Luo, Jingdong5,6 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2021-07-28 |
| 页码 | 10 |
| 关键词 | molecular motion nonplanar small molecules photoacoustic imaging photochemical reaction photothermal therapy |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202102799 |
| 英文摘要 | There has been much recent progress in the development of photothermal agents (PTAs) for biomedical and energy applications. Synthesis of organic PTAs typically involves noble metal catalysts and high temperatures. On the other hand, photochemical synthesis, as an alternative and green chemical technology, has obvious merits such as low cost, energy efficiency, and high yields. However, photochemical reactions have rarely been employed for the synthesis of PTAs. Herein, a facile and high-yield photochemical reaction is exploited for synthesizing nonplanar small molecules (NSMs) containing strong Michler's base donors and a tricyanoquinodimethane acceptor as high-performance PTAs. The synthesized NSMs show interesting photophysical properties including good absorption for photons of over 1000 nm wavelength, high near-infrared extinction coefficients, and excellent photothermal performance. Upon assembling the NSMs into nanoparticles (NSMN), they exhibit good biocompatibility, high photostability, and excellent photothermal conversion efficiency of 75%. Excited-state dynamic studies reveal that the NSMN has ultrafast nonradiative decay after photoexcitation. With these unique properties, the NSMN achieves efficient in vivo photoacoustic imaging and photothermal tumor ablation. This work demonstrates the superior potential of photochemical reactions for the synthesis of high-performance molecular PTAs. |
| WOS关键词 | SEMICONDUCTING POLYMER NANOPARTICLES ; PHOTOTHERMAL MATERIALS ; ORGANIC NANOPARTICLES ; CARBON NANOTUBES ; PERFORMANCE ; CHROMOPHORES ; AGENTS |
| 资助项目 | University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region via the GRF project[CityU 11300320] ; Natural Science Foundation of China[21975213] ; City University of Hong Kong[9610454] ; City University of Hong Kong[9680263] ; City University of Hong Kong[9610389] ; General Research Fund of HKSAR (RGC)[11306320] ; Shenzhen Science & Technology Innovation Committee[JCYJ20180507181718203] ; National Natural Science Foundation of China[32000988] ; China Postdoctoral Science Foundation[2019TQ0212] ; China Postdoctoral Science Foundation[2020M672832] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000678193600001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region via the GRF project ; Natural Science Foundation of China ; City University of Hong Kong ; General Research Fund of HKSAR (RGC) ; Shenzhen Science & Technology Innovation Committee ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/49543]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Lu, Guihong; Li, Shengliang; Luo, Jingdong; Lee, Chun-Sing |
| 作者单位 | 1.Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China 2.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 3.Shenzhen Univ, Coll Phys & Optoelect Engn, Shenzhen 518060, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China 5.City Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Peoples R China 6.City Univ Hong Kong, Dept Chem, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China 7.City Univ Hong Kong, Joint Lab Nanoorgan Funct Mat & Devices TIPC & Ci, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China 8.City Univ Hong Kong, Dept Chem, Ctr Super Diamond & Adv Films COSDAF, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaozhen,Zhang, Di,Lu, Guihong,et al. Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics[J]. ADVANCED MATERIALS,2021:10. |
| APA | Li, Xiaozhen.,Zhang, Di.,Lu, Guihong.,He, Tingchao.,Wan, Yingpeng.,...&Lee, Chun-Sing.(2021).Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics.ADVANCED MATERIALS,10. |
| MLA | Li, Xiaozhen,et al."Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics".ADVANCED MATERIALS (2021):10. |
入库方式： OAI收割
来源：过程工程研究所
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