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Antifungal azoles and azole resistance in the environment: current status and future perspectives-a review

文献类型：期刊论文

作者Assress, Hailemariam Abrha1,2,3; Selvarajan, Ramganesh4,5; Nyoni, Hlengilizwe1; Mamba, Bhekie B.1,6; Msagati, Titus A. M.1
刊名REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY
出版日期2021-10-07
页码31
关键词Occurrence Azole antifungal drugs Azole resistance Future perspectives Fungi Environment
ISSN号1569-1705
DOI10.1007/s11157-021-09594-w
英文摘要Following their extensive use, azole antifungals may enter the environment through the discharge of domestic, industrial and hospital wastewaters, agricultural runoffs and as leachates in waste-disposal sites. The presence of the azole antifungals poses potential toxicity risks to non-target organisms and plays a critical role in the evolution and/or selection of azole resistant fungal strains in the environment. Toxicities such as inhibition of algal growth, endocrine disruption in fish, CYP450-effected steroidogenesis, modulating sex differentiation in frogs, and reduction of larval body mass and growth rate have been related to azole antifungals. In addition, the isolation of azole resistant fungi such as Aspergillus fumigatus in both the environment and clinic retaining similar mode of molecular drug resistance mechanism has drawn the attention of many researchers. Therefore, the investigation of the occurrence and distribution of azole antifungals as well as azole resistant environmental isolates of fungi is becoming a trendy research venue. Here we review the occurrence of antifungal azoles and azole resistance in the environment. The major points discussed are (1) an update on the environmental occurrence, distribution and ecological risks of the most commonly used azole antifungals in the environment including surface water and drinking water (2) environmental azole antifungal resistance, predominant molecular mechanisms of azole resistance in the environment, and the implications for human health (3) future trends and perspectives that could help reduce the ecological and human health risks of azoles and tackle the spread of azole resistance in the environment, and hence in the clinic.
WOS关键词PERSONAL CARE PRODUCTS ; SOLID-PHASE EXTRACTION ; EPIDEMIOLOGIC CUTOFF VALUES ; ASPERGILLUS-FUMIGATUS ; DRUG-RESISTANCE ; WASTE-WATER ; IN-VITRO ; LIQUID-CHROMATOGRAPHY ; CROSS-RESISTANCE ; PHARMACEUTICAL COMPOUNDS
资助项目Institute for Nanotechnology and Water Sustainability, UNISA, South Africa ; Addis Ababa University, Ethiopia
WOS研究方向Biotechnology & Applied Microbiology ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000705745100001
出版者SPRINGER
资助机构Institute for Nanotechnology and Water Sustainability, UNISA, South Africa ; Addis Ababa University, Ethiopia
源URL[http://ir.idsse.ac.cn/handle/183446/8835]  
专题深海科学研究部_地外海洋系统研究室
通讯作者Msagati, Titus A. M.
作者单位1.Univ South Africa, Inst Nanotechnol & Water Sustainabil, Coll Sci Engn & Technol, UNISA Sci Campus,POB 392,UNISA 0003, ZA-1709 Johannesburg, South Africa
2.Arkansas Childrens Nutr Ctr, 15 Childrens Way, Little Rock, AR 72202 USA
3.Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR USA
4.Univ South Africa, Coll Agr & Environm Sci, UNISA Sci Campus,POB 392,UNISA 0003, ZA-1709 Johannesburg, South Africa
5.Chinese Acad Sci, Inst Deep Sea Sci & Engn, LEOS, 28 Luhuitou Rd, Sanya 572000, Hainan, Peoples R China
6.Natl Ctr Int Joint Res Membrane Sci & Technol, State Key Lab Separat Membranes & Membrane Proc, Tianjin 300387, Peoples R China
推荐引用方式
GB/T 7714		 Assress, Hailemariam Abrha,Selvarajan, Ramganesh,Nyoni, Hlengilizwe,et al. Antifungal azoles and azole resistance in the environment: current status and future perspectives-a review[J]. REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY,2021:31.
APA Assress, Hailemariam Abrha,Selvarajan, Ramganesh,Nyoni, Hlengilizwe,Mamba, Bhekie B.,&Msagati, Titus A. M..(2021).Antifungal azoles and azole resistance in the environment: current status and future perspectives-a review.REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY,31.
MLA Assress, Hailemariam Abrha,et al."Antifungal azoles and azole resistance in the environment: current status and future perspectives-a review".REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY (2021):31.

入库方式： OAI收割

来源：深海科学与工程研究所

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