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Host-Endosymbiont Genome Integration in a Deep-Sea Chemosymbiotic Clam
文献类型：期刊论文
| 作者 | Ip, Jack Chi-Ho1,2,3; Xu, Ting1,2,3; Sun, Jin3,4 ; Li, Runsheng5; Chen, Chong6; Lan, Yi3,4; Han, Zhuang7; Zhang, Haibin7; Wei, Jiangong8; Wang, Hongbin8
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| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
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| 出版日期 | 2021-02-01 |
| 卷号 | 38期号:2页码:502-518 |
| 关键词 | cold seep genome assembly genome erosion hydrothermal vent Mollusca symbiosis |
| ISSN号 | 0737-4038 |
| DOI | 10.1093/molbev/msaa241 |
| 英文摘要 | Endosymbiosis with chemosynthetic bacteria has enabled many deep-sea invertebrates to thrive at hydrothermal vents and cold seeps, but most previous studies on this mutualism have focused on the bacteria only. Vesicomyid clams dominate global deep-sea chemosynthesis-based ecosystems. They differ from most deep-sea symbiotic animals in passing their symbionts from parent to offspring, enabling intricate coevolution between the host and the symbiont. Here, we sequenced the genomes of the clam Archivesica marissinica (Bivalvia: Vesicomyidae) and its bacterial symbiont to understand the genomic/metabolic integration behind this symbiosis. At 1.52 Gb, the clam genome encodes 28 genes horizontally transferred from bacteria, a large number of pseudogenes and transposable elements whose massive expansion corresponded to the timing of the rise and subsequent divergence of symbiont-bearing vesicomyids. The genome exhibits gene family expansion in cellular processes that likely facilitate chemoautotrophy, including gas delivery to support energy and carbon production, metabolite exchange with the symbiont, and regulation of the bacteriocyte population. Contraction in cellulase genes is likely adaptive to the shift from phytoplankton-derived to bacteria-based food. It also shows contraction in bacterial recognition gene families, indicative of suppressed immune response to the endosymbiont. The gammaproteobacterium endosymbiont has a reduced genome of 1.03 Mb but retains complete pathways for sulfur oxidation, carbon fixation, and biosynthesis of 20 common amino acids, indicating the host's high dependence on the symbiont for nutrition. Overall, the host-symbiont genomes show not only tight metabolic complementarity but also distinct signatures of coevolution allowing the vesicomyids to thrive in chemosynthesis-based ecosystems. |
| 资助项目 | National Key R&D Program, Ministry of Science and Technology, China[2018YFC0310005] ; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)[GML2019ZD0409] ; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)[L20190005] ; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)[GML2019ZD0404] ; General Research Fund from the University Grants Committee of Hong Kong Special Administrative Region[12302917] ; State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University[SKLP_1920_P04] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000637318600014 |
| 出版者 | OXFORD UNIV PRESS |
| 资助机构 | National Key R&D Program, Ministry of Science and Technology, China ; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) ; General Research Fund from the University Grants Committee of Hong Kong Special Administrative Region ; State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University |
| 源URL | [http://ir.idsse.ac.cn/handle/183446/8672]  |
| 专题 | 深海科学研究部_深海生物学研究室_深海微生物活性物质研究组 |
| 通讯作者 | Qiu, Jian-Wen |
| 作者单位 | 1.Hong Kong Baptist Univ, Dept Biol, Hong Kong, Peoples R China 2.HKBU Inst Res & Continuing Educ, Virtual Univ Pk, Shenzhen, Peoples R China 3.Hong Kong Univ Sci & Technol, Southern Marine Sci & Engn Guangdong Lab Guangzho, Hong Kong Branch, Hong Kong, Peoples R China 4.Hong Kong Univ Sci & Technol, Dept Ocean Sci, Div Life Sci, Hong Kong, Peoples R China 5.City Univ Hong Kong, Jockey Club Coll Vet Med & Life Sci, Dept Infect Dis & Publ Hlth, Hong Kong, Peoples R China 6.Japan Agcy Marine Earth Sci & Technol JAMSTEC, X STAR, Yokosuka, Kanagawa, Japan 7.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Sanya, Hainan, Peoples R China 8.China Geol Survey, MLR Key Lab Marine Mineral Resources, Guangzhou Marine Geol Survey, Guangzhou, Peoples R China 9.Hong Kong Baptist Univ, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ip, Jack Chi-Ho,Xu, Ting,Sun, Jin,et al. Host-Endosymbiont Genome Integration in a Deep-Sea Chemosymbiotic Clam[J]. MOLECULAR BIOLOGY AND EVOLUTION,2021,38(2):502-518. |
| APA | Ip, Jack Chi-Ho.,Xu, Ting.,Sun, Jin.,Li, Runsheng.,Chen, Chong.,...&Qiu, Jian-Wen.(2021).Host-Endosymbiont Genome Integration in a Deep-Sea Chemosymbiotic Clam.MOLECULAR BIOLOGY AND EVOLUTION,38(2),502-518. |
| MLA | Ip, Jack Chi-Ho,et al."Host-Endosymbiont Genome Integration in a Deep-Sea Chemosymbiotic Clam".MOLECULAR BIOLOGY AND EVOLUTION 38.2(2021):502-518. |
入库方式： OAI收割
来源：深海科学与工程研究所
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