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Tuning cell adhesion on supported lipid bilayers via nanoscale geometry

文献类型：期刊论文

作者Li, Long4,5; Gao, Jie2,3; Shao, Yingfeng4,5; Song, Fan1,4,5; Hu, Jinglei2,3; Song F(宋凡); Hu JL; Li L(李龙); Shao YF(邵颖峰)
刊名SOFT MATTER
出版日期2021-10-20
页码7
ISSN号1744-683X
DOI10.1039/d1sm01407b
通讯作者Shao, Yingfeng(shaoyf@lnm.imech.ac.cn) ; Hu, Jinglei(hujinglei@nju.edu.cn)
英文摘要The cell-supported lipid bilayer (SLB) adhesion system has been widely used as the model system to study the receptor-ligand interactions that occur at the membrane interface. The ligand-functionalized SLBs are deposited either directly on solids or on polymer cushions. An important question that arises is whether the geometry of the SLB affects the binding of cell adhesion receptors to the ligands. By using a mesoscopic mechanical model and Monte Carlo simulations, we have investigated the adhesion of a fluid membrane to a corrugated or egg-carton shaped SLB. We find that the nanoscale geometry of the SLB strongly affects the receptor-ligand binding. This effect results from the fact that the adhering membrane bends according to the SLB geometry in order for the adhesion receptors to bind ligands. The membrane bending couples with spatial distribution of the receptor-ligand complexes and membrane thermal undulations. Our results demonstrate that cell adhesion to SLBs can be controlled by tuning the nanoscale geometry of the SLB, and may have profound implications for future development of tissue engineering and regenerative medicine.
WOS关键词MEMBRANE-ANCHORED RECEPTORS ; BINDING ; KINETICS ; LIGANDS ; CONSTANTS ; ANTIGEN ; RAFTS ; SELF
资助项目National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; National Natural Science Foundation of China[21973040] ; National Natural Science Foundation of China[21504038] ; Youth Innovation Promotion Association CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102]
WOS研究方向Chemistry ; Materials Science ; Physics ; Polymer Science
语种英语
WOS记录号WOS:000715423600001
资助机构National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://dspace.imech.ac.cn/handle/311007/87895]  
专题力学研究所_非线性力学国家重点实验室
通讯作者Shao, Yingfeng; Hu, Jinglei
作者单位1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
2.Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China
3.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China
4.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Long,Gao, Jie,Shao, Yingfeng,et al. Tuning cell adhesion on supported lipid bilayers via nanoscale geometry[J]. SOFT MATTER,2021:7.
APA Li, Long.,Gao, Jie.,Shao, Yingfeng.,Song, Fan.,Hu, Jinglei.,...&邵颖峰.(2021).Tuning cell adhesion on supported lipid bilayers via nanoscale geometry.SOFT MATTER,7.
MLA Li, Long,et al."Tuning cell adhesion on supported lipid bilayers via nanoscale geometry".SOFT MATTER (2021):7.

入库方式： OAI收割

来源：力学研究所

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