Effect of drag-reducing polymer on blood flow in microchannels
文献类型：期刊论文
| 作者 | Li, Guanjie3; Sun, Yang3; Zheng, Xu2; Choi, Hyoung Jin1; Zhang, Ke3
|
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2022 |
| 卷号 | 209页码:7 |
| ISSN号 | 0927-7765 |
| 关键词 | Hyaluronic acid Red blood cell Velocity Cell-free layer Microcirculation |
| DOI | 10.1016/j.colsurfb.2021.112212 |
| 通讯作者 | Zheng, Xu(zhengxu@lnm.imech.ac.cn) ; Zhang, Ke(zhangke@hit.edu.cn) |
| 英文摘要 | Drag-reducing polymers (DRPs) can significantly improve blood circulation when added to blood at a nanomolar concentration, manifesting great potential for application in the biomedical field. In this work, hyaluronic acid (HA) was selected as a natural DRP, and its effects on blood microcirculation at different concentrations, flow rates, and channel geometry were studied in microchannels. The experimental results show that adding a small dose of HA can increase the velocity and shorten the thickness of the cell-free layer (CFL or cell depletion layer (CDL)) near the wall. After considering efficiency, our experiments determined 50 ppm addition of HA to be the most suitable amount for improving blood circulation. Our results demonstrate that HA has high efficiency in improving the circulation of blood flow and shed light on unveiling the mechanism of using natural DRPs to cure some cardiovascular diseases. |
| WOS关键词 | FREE LAYER WIDTH ; CELL ; MARGINATION ; AGGREGATION ; MICROCIRCULATION ; REDUCTION ; PERFUSION ; OXIDE |
| 资助项目 | National Natural Science Foundation of China[51603056] ; National Natural Science Foundation of China[11572335] ; Excellent Youth Foundation of Heilongjiang Province of China[YQ2019E020] ; CAS Key Research Program of Frontier Sciences[QYZDB-SSW-JSC036] ; CAS Strategic Priority Research Program[XDB22040403] |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000720947900004 |
| 资助机构 | National Natural Science Foundation of China ; Excellent Youth Foundation of Heilongjiang Province of China ; CAS Key Research Program of Frontier Sciences ; CAS Strategic Priority Research Program |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/87996]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 通讯作者 | Zheng, Xu; Zhang, Ke |
| 作者单位 | 1.Inha Univ, Dept Polymer Sci & Engn, Incheon 22212, South Korea 2.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China 3.Harbin Inst Technol, MITT Key Lab Crit Mat Technol New Energy Convers, Sch Chem & Chem Engn, Harbin 150001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Guanjie,Sun, Yang,Zheng, Xu,et al. Effect of drag-reducing polymer on blood flow in microchannels[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2022,209:7. |
| APA | Li, Guanjie,Sun, Yang,Zheng, Xu,Choi, Hyoung Jin,&Zhang, Ke.(2022).Effect of drag-reducing polymer on blood flow in microchannels.COLLOIDS AND SURFACES B-BIOINTERFACES,209,7. |
| MLA | Li, Guanjie,et al."Effect of drag-reducing polymer on blood flow in microchannels".COLLOIDS AND SURFACES B-BIOINTERFACES 209(2022):7. |
入库方式： OAI收割
来源：力学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。