Edible Bird's Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte
文献类型：期刊论文
| 作者 | Lai, Queenie Wing Sze3,4,5; Guo, Maggie Sui Sui3,4,5; Wu, Kevin Qiyun3,4,5; Liao, Zhitao2; Guan, Dongshi1; Dong, Tina Tingxia3,4,5; Tong, Penger2; Tsim, Karl Wah Keung3,4,5 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2021-07-20 |
| 卷号 | 12页码:18 |
| 关键词 | edible bird's nest sialic acid moisturizing filaggrin filaggrin-2 atomic force microscopy |
| DOI | 10.3389/fphar.2021.685982 |
| 通讯作者 | Tsim, Karl Wah Keung(botsim@ust.hk) |
| 英文摘要 | Edible bird's nest (EBN) has been consumed as a Chinese delicacy for hundreds of years; the functions of which have been proposed to prevent lung disease, strengthen immune response, and restore skin youthfulness. To support the skin function of EBN, the water extract and the enzymatic digest of EBN with enriched digested peptides were tested in cultured keratinocyte, HaCaT cell line. The effects of EBN extract and digest in inducing proteins crucial for skin moisturizing were determined in both in vitro and ex vivo models. In cultured keratinocytes, the expressions of S100-fused type proteins contributing to skin barrier function in the stratum corneum, e.g. filaggrin and filaggrin-2, were determined in both mRNA and protein levels, which were markedly induced in the treatment of EBN extract or digest. The EBN-induced gene transcriptions of filaggrin and filaggrin-2 were mediated by activation of p38 MAPK pathway and various transcription factors, e.g. GATA3, PPAR alpha, PPAR beta, and PPAR gamma: these transcriptional factors were markedly activated by the digested products of EBN, as compared to the extract, in cultured keratinocytes. By using atomic force microscopy (AFM), the EBN-treated keratinocyte was shown to have more liquid-like morphology, as compared to a control cell. The EBN digest showed better induction on these moisturizing effects as compared to the extract. These lines of evidence therefore suggested the water moisturizing effect of EBN in skin function. |
| WOS关键词 | ACTIVATED RECEPTORS PPARS ; INHIBITS PROLIFERATION ; CASPASE-14 EXPRESSION ; DIFFERENTIATION ; CELLS ; MUTATIONS ; MODULATION ; LIGANDS ; CALCIUM ; PATHWAY |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000721538700001 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/88002]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 通讯作者 | Tsim, Karl Wah Keung |
| 作者单位 | 1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China 2.Hong Kong Univ Sci & Technol, Dept Phys, Hong Kong, Peoples R China 3.Hong Kong Univ Sci & Technol, Ctr Chinese Med R&D, Hong Kong, Peoples R China 4.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Peoples R China 5.Hong Kong Univ Sci & Technol, Shenzhen Res Inst, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lai, Queenie Wing Sze,Guo, Maggie Sui Sui,Wu, Kevin Qiyun,et al. Edible Bird's Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte[J]. FRONTIERS IN PHARMACOLOGY,2021,12:18. |
| APA | Lai, Queenie Wing Sze.,Guo, Maggie Sui Sui.,Wu, Kevin Qiyun.,Liao, Zhitao.,Guan, Dongshi.,...&Tsim, Karl Wah Keung.(2021).Edible Bird's Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte.FRONTIERS IN PHARMACOLOGY,12,18. |
| MLA | Lai, Queenie Wing Sze,et al."Edible Bird's Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte".FRONTIERS IN PHARMACOLOGY 12(2021):18. |
入库方式： OAI收割
来源：力学研究所
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