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Rapid SERS identification of methicillin-susceptible and methicillin-resistant Staphylococcus aureus via aptamer recognition and deep learning

文献类型：期刊论文

作者Wang, Shu1,2; Dong, Hao1,2; Shen, Wanzhu4; Yang, Yong1,2; Li, Zhigang1; Liu, Yong1,2; Wang, Chongwen4; Gu, Bing3; Zhang, Long1,2
刊名RSC ADVANCES
出版日期2021-10-25
卷号11
DOI10.1039/d1ra05778b
通讯作者Wang, Chongwen(wangchongwen1987@126.com) ; Gu, Bing(gb20031129@163.com) ; Zhang, Long(zhanglong@aiofm.ac.cn)
英文摘要Here, we report a label-free surface-enhanced Raman scattering (SERS) method for the rapid and accurate identification of methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) based on aptamer-guided AgNP enhancement and convolutional neural network (CNN) classification. Sixty clinical isolates of Staphylococcus aureus (S. aureus), comprising 30 strains of MSSA and 30 strains of MRSA were used to build the CNN classification model. The developed method exhibited 100% identification accuracy for MSSA and MRSA, and is thus a promising tool for the rapid detection of drug-sensitive and drug-resistant bacterial strains.
WOS关键词RAMAN-SPECTROSCOPY ; BACTERIA ; LABEL ; NANOPARTICLES
资助项目National Natural Science Foundation of China[81871734] ; National Natural Science Foundation of China[81471994] ; Natural Science Foundation of Anhui Province[1908085QB85] ; Postgraduate Research & Practice Innovation Program of Jiangsu Province[KYCX20_2472] ; Medical instrument supervise program of Hefei institute of physical science of CAS[YZJJ2021-J-YQ4]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000710635200001
出版者ROYAL SOC CHEMISTRY
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Postgraduate Research & Practice Innovation Program of Jiangsu Province ; Medical instrument supervise program of Hefei institute of physical science of CAS
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/125723]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Chongwen; Gu, Bing; Zhang, Long
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei 230036, Peoples R China
2.Univ Sci & Technol China, Hefei 230036, Peoples R China
3.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Lab Med, Guangzhou 510000, Peoples R China
4.Anhui Agr Univ, Hefei 230036, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Shu,Dong, Hao,Shen, Wanzhu,et al. Rapid SERS identification of methicillin-susceptible and methicillin-resistant Staphylococcus aureus via aptamer recognition and deep learning[J]. RSC ADVANCES,2021,11.
APA Wang, Shu.,Dong, Hao.,Shen, Wanzhu.,Yang, Yong.,Li, Zhigang.,...&Zhang, Long.(2021).Rapid SERS identification of methicillin-susceptible and methicillin-resistant Staphylococcus aureus via aptamer recognition and deep learning.RSC ADVANCES,11.
MLA Wang, Shu,et al."Rapid SERS identification of methicillin-susceptible and methicillin-resistant Staphylococcus aureus via aptamer recognition and deep learning".RSC ADVANCES 11(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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