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Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation

文献类型：期刊论文

作者Fan, Xiaoqing1,2,3,4; Fan, Junqi1,2,3; Yang, Haoran1,2,5; Zhao, Chenggang1,2,3; Niu, Wanxiang1,2,3; Fang, Zhiyou1,2,5; Chen, Xueran1,2,5
刊名ONCOGENESIS
出版日期2021-10-27
卷号10
ISSN号2157-9024
DOI10.1038/s41389-021-00361-8
通讯作者Fang, Zhiyou(zyfang@cmpt.ac.cn) ; Chen, Xueran(xueranchen@cmpt.ac.cn)
英文摘要Glioblastoma (GBM) is the most common and deadly of the primary intracranial tumors and is comprised of subsets that show plasticity and marked heterogeneity, contributing to the lack of success in genomic profiling to guide development of precision medicine for these tumors. In this study, a mutation in isocitrate dehydrogenase 1 was found to suppress the transforming growth factor-beta signaling pathway and E2F4 interacted with Smad3 to inhibit expression of mesenchymal markers. However, palmitoylation of Smad3 mediated by palmitoyltransferase ZDHHC19 promoted activation of the transforming growth factor-beta signaling pathway, and its interaction with EP300 promoted expression of mesenchymal markers in the mesenchymal subtype of GBM. Smad3 and hypoxia-inducible factor 1-alpha may be important molecular targets for treatment of glioma because they appear to coordinate the basic aspects of cancer stem cell biology.
WOS关键词GLIOMA ; TGF-BETA-1 ; PROTEINS ; SUBTYPES ; THERAPY ; IDH1 ; EGFR
资助项目National Natural Science Foundation of China[82172663] ; National Natural Science Foundation of China[82104208] ; National Natural Science Foundation of China[81872066] ; National Natural Science Foundation of China[81773131] ; National Natural Science Foundation of China[81972635] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2018487] ; National Key R&D Program of China[2017YFA0503600]
WOS研究方向Oncology
语种英语
出版者SPRINGERNATURE
WOS记录号WOS:000712573700001
资助机构National Natural Science Foundation of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; National Key R&D Program of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/125747]  
专题中国科学院合肥物质科学研究院
通讯作者Fang, Zhiyou; Chen, Xueran
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Anhui Prov Key Lab Med Phys & Technol, 350 Shushan Hu Rd, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, MOE Key Lab Membraneless Organelles & Cellular Dy, 96 Jin Zhai Rd, Hefei 230027, Anhui, Peoples R China
3.Univ Sci & Technol China, 96 Jin Zhai Rd, Hefei 230031, Anhui, Peoples R China
4.Univ Sci & Technol China USTC, Div Life Sci & Med, Affiliated Hosp USTC 1, Dept Anesthesiol, 17 Lu Jiang Rd, Hefei 230001, Anhui, Peoples R China
5.Chinese Acad Sci, Hefei Canc Hosp, Dept Lab Med, 350 Shushan Hu Rd, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Fan, Xiaoqing,Fan, Junqi,Yang, Haoran,et al. Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation[J]. ONCOGENESIS,2021,10.
APA Fan, Xiaoqing.,Fan, Junqi.,Yang, Haoran.,Zhao, Chenggang.,Niu, Wanxiang.,...&Chen, Xueran.(2021).Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation.ONCOGENESIS,10.
MLA Fan, Xiaoqing,et al."Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation".ONCOGENESIS 10(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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