Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy
文献类型：期刊论文
| 作者 | Dang, Zheng2; Guan, Yong2; Wu, Zhao2; Tao, Xia-Yu2; Xiong, Ying2; Bai, Hao-Bo2; Shao, Chang-Sheng1,3; Liu, Gang2; Huang, Qing1,3; Tian, Li-Jiao2 |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2021-10-11 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/d1nr03591f |
| 通讯作者 | Tian, Li-Jiao(ljtian@ustc.edu.cn) ; Tian, Yang-Chao(ychtian@ustc.edu.cn) |
| 英文摘要 | Biosynthesis has gained growing interest due to its energy efficiency and environmentally benign nature. Recently, biogenic iron sulfide nanoparticles (FeS NPs) have exhibited excellent performance in environmental remediation and energy recovery applications. However, their biosynthesis regulation strategy and application prospects in the biomedical field remain to be explored. Herein, biogenic FeS NPs are controllably synthesized by Shewanella oneidensis MR-1 and applied for cancer therapy. Tuning the synthesis rate and yield of biogenic FeS NPs is realized by altering the initial iron precursor dosage. Notably, increasing the precursor concentration decreases and delays FeS NP biosynthesis. The biogenic FeS NPs (30 nm) are homogeneously anchored on the cell surface of S. oneidensis MR-1. Moreover, the good hydrophilic nature and outstanding Fenton properties of the as-prepared FeS NPs endow them with good cancer therapy performance. The intracellular location of the FeS NPs taken up is visualized with a soft X-ray microscope (SXM). Highly efficient cancer cell killing can be achieved at extremely low concentrations (<12 mu g mL(-1)), lower than those in reported works. Such good performance is attributed to the Fe2+ release, elevated ROS, reduced glutathione (GSH) consumption, and lipid hydroperoxide (LPO) generation. The resulting FeS NPs show excellent in vivo therapeutic performance. This work provides a facile, eco-friendly, and scalable approach to produce nanomedicine, demonstrating the potential of biogenic nanoparticles for use in cancer therapy. |
| WOS关键词 | QUANTUM DOTS ; SHEWANELLA ; BIOSYNTHESIS |
| 资助项目 | National Key Research and Development Program of China[2017YFA0402904] ; National Natural Science Foundation of China[21907087] ; National Natural Science Foundation of China[11775224] ; National Natural Science Foundation of China[U2032148] ; Natural Science Foundation of Anhui Province[1908085MB31] ; Fundamental Research Funds for the Central Universities[WK2060000003] ; Fundamental Research Funds for the Central Universities[WK2310000100] ; Youth Innovation Promotion Association, CAS[2020457] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000711597100001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Fundamental Research Funds for the Central Universities ; Youth Innovation Promotion Association, CAS |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/125780]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Tian, Li-Jiao; Tian, Yang-Chao |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, CAS Key Lab High Magnet Field & Ion Beam Phys Bio, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Natl Synchrotron Radiat Lab, Hefei 230026, Peoples R China 3.Univ Sci & Technol China, Sci Isl Branch, Grad Sch, Hefei 230026, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dang, Zheng,Guan, Yong,Wu, Zhao,et al. Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy[J]. NANOSCALE,2021. |
| APA | Dang, Zheng.,Guan, Yong.,Wu, Zhao.,Tao, Xia-Yu.,Xiong, Ying.,...&Tian, Yang-Chao.(2021).Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy.NANOSCALE. |
| MLA | Dang, Zheng,et al."Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy".NANOSCALE (2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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