A Novel Matrix of Sequence Descriptors for Predicting Protein-Protein Interactions from Amino Acid Sequences.
文献类型：期刊论文
| 作者 | Wang X(王雪) ; Yuejin Wu; Rujing Wang; Yuanyuan Wei; Yuanmiao Gui
|
| 刊名 | Plos one
 |
| 出版日期 | 2019-06-07 |
| ISSN号 | 0218-3390 |
| DOI | doi.org/10.1371/journal.pone.0217312 |
| 英文摘要 | Protein-protein interactions (PPIs) play an important role in the life activities of organisms. With the availability of large amounts of protein sequence data, PPIs prediction methods have attracted increasing attention. A variety of protein sequence coding methods have emerged, but the training of these methods is particularly time consuming. To solve this issue, we have proposed a novel matrix sequence coding method. Based on deep neural network (DNN) and a novel matrix protein sequence descriptor, we constructed a protein interaction prediction model for predicting PPIs. When performed on human PPIs data, the method achieved an accuracy of 94.34%, a recall of 98.28%, an area under the curve
(AUC) of 97.79% and a loss of 23.25%. A non-redundant dataset was used to evaluate this prediction model, and the prediction accuracy is 88.29%. These results indicate that the matrix of sequence (MOS) descriptor can enhance the predictive power of PPIs and reduce training time, which can be a useful complement for future proteomics research. The experimental code and experimental results can be found at https://github.com/smalltalkman/
hppi-tensorflow. |
| URL标识 | 查看原文 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/126104]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Yuanmiao Gui |
| 作者单位 | Institute of Technical Biology & Agriculture Engineering, Chinese Academy of Sciences |
| 推荐引用方式 GB/T 7714 | Wang X,Yuejin Wu,Rujing Wang,et al. A Novel Matrix of Sequence Descriptors for Predicting Protein-Protein Interactions from Amino Acid Sequences.[J]. Plos one,2019. |
| APA | Wang X,Yuejin Wu,Rujing Wang,Yuanyuan Wei,&Yuanmiao Gui.(2019).A Novel Matrix of Sequence Descriptors for Predicting Protein-Protein Interactions from Amino Acid Sequences..Plos one. |
| MLA | Wang X,et al."A Novel Matrix of Sequence Descriptors for Predicting Protein-Protein Interactions from Amino Acid Sequences.".Plos one (2019). |
入库方式： OAI收割
来源：合肥物质科学研究院
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