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Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer

文献类型：期刊论文

作者Gan, Yuehao1,2; Zhang, Jia1; Lei, Shulai4; Yan, Miao3; Xie, Wenteng1,2; Qi, Xiangyu3; Wang, Huijuan2; Xiao, Jianmin3; Chen, Siyang; Li, Shujuan
刊名CHEMICAL ENGINEERING JOURNAL
出版日期2022-02-01
卷号429
ISSN号1385-8947
关键词Gd doping Magnetic iron oxide nanoclusters Atomically precise MRI T-2-weighted contrast agents
DOI10.1016/j.cej.2021.132255
通讯作者Zhang, Guilong(glzhang@bzmc.edu.cn) ; Wu, Zhengyan(zywu@ipp.ac.cn)
英文摘要The use of multi-domain magnetic iron oxide nanoclusters (MMIONs) as Magnetic resonance imaging (MRI) contrast agent is facing problems of strong ferromagnetism and thus weak T-2 contrast ability. The doping of Gd ions holds potential to solve these problems by reducing ferromagnetism and enhancing transverse relaxivity (r(2)), but the exact role of doping in modulating the contrast properties remain unknown. Herein, we prepared a series of atomically precise GdxFe3-xO4 nanoclusters and systematically explored the effect of Gd doping on tuning their morphology, magnetic property, and r(2) value. After the doping of Gd ions, the specific surface area of GdxFe3-xO4 nanoclusters significantly increased, and meanwhile, the magnetic property of GdxFe3-xO4 nanoclusters transformed from ferromagnetism to superparamagnetism, which led to stronger T-2 contrast. Specifically, the highest r(2) value was obtained at 488 mM(-1)s(-1) (7.0 T) for Gd0.072Fe2.928O4 nanocluster, four times higher than that for pristine Fe3O4 (110 mM(-1)s(-1)). For potential applications, we validated the outstanding contrast of Gd0.018Fe2.982O4 nanocluster (r(2) = 481 mM(-1)s(-1) at 7.0 T) to diagnose early orthotopic cancer in mice. This work opens up a new avenue for the development of atomically precise Gd-doped MMIONs as efficient T-2-weighted MRI contrast agents.
WOS关键词TOTAL-ENERGY CALCULATIONS ; IRON-OXIDE NANOPARTICLES ; PROSTATE-CANCER ; PERFORMANCE ; MRI ; DELIVERY ; SIZE
资助项目Natural Science Foundation of Anhui Province[1808085MB38] ; National Natural Science Foundation of China[22007006] ; National Natural Science Foundation of China[31771284] ; National Natural Science Foundation of China[81401518] ; National Natural Science Foundation of China[31430028] ; Special Project of Central Government for Local Science and Technology Development of Shandong Province[YDZX20203700001291] ; Taishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; Shandong Provincial Natural Science Foundation[ZR2016JL026] ; Key Research and Development Plan of Shandong Province[2018GSF118230]
WOS研究方向Engineering
语种英语
出版者ELSEVIER SCIENCE SA
WOS记录号WOS:000728529900001
资助机构Natural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; Special Project of Central Government for Local Science and Technology Development of Shandong Province ; Taishan Scholars Construction Engineering ; Shandong Provincial Natural Science Foundation ; Key Research and Development Plan of Shandong Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/126452]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Guilong; Wu, Zhengyan
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
2.Univ Sci & Technol China, Engn & Mat Sci Expt Ctr, Hefei 230026, Peoples R China
3.Binzhou Med Univ, Key Lab Prescript Effect & Clin Evaluat State Adm, Sch Pharm, Yantai 264003, Peoples R China
4.Hubei Univ Arts & Sci, Hubei Key Lab Low Dimens Optoelect Mat & Devices, Xiangyang 441053, Peoples R China
推荐引用方式
GB/T 7714		 Gan, Yuehao,Zhang, Jia,Lei, Shulai,et al. Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer[J]. CHEMICAL ENGINEERING JOURNAL,2022,429.
APA Gan, Yuehao.,Zhang, Jia.,Lei, Shulai.,Yan, Miao.,Xie, Wenteng.,...&Wu, Zhengyan.(2022).Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer.CHEMICAL ENGINEERING JOURNAL,429.
MLA Gan, Yuehao,et al."Atomically precise multi-domain GdxFe3-xO4 nanoclusters with modulated contrast properties for T-2-weighted magnetic resonance imaging of early orthotopic cancer".CHEMICAL ENGINEERING JOURNAL 429(2022).

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来源：合肥物质科学研究院

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