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Simultaneous enhancement of T-1 and T-2 magnetic resonance imaging of liver tumor at respective low and high magnetic fields

文献类型：期刊论文

作者Li, Huan2; Hai, Zijuan1; Zou, Liwei2; Zhang, Lele1; Wang, Lulu4; Wang, Longsheng2; Liang, Gaolin3
刊名THERANOSTICS
出版日期2022
卷号12
ISSN号1838-7640
关键词gamma-glutamyl transpeptidase gadolinium nanoparticle magnetic resonance imaging liver tumor tumor imaging
DOI10.7150/thno.67155
通讯作者Wang, Longsheng(wanglongsheng@ahmu.edu.cn) ; Liang, Gaolin(gliang@seu.edu.cn)
英文摘要Background: Nowadays, magnetic resonance imaging (MRI) is routinely applied in clinical diagnosis. However, using one contrast agent (CA) to simultaneously enhance the T-1 and T-2 MR contrast at low and high magnetic fields respectively has not been reported. Methods: Herein, we investigated the MR property of a gamma-glutamyl transpeptidase (GGT)-instructed, intracellular formed gadolinium nanoparticle (DOTA-Gd-CBT-NP) at low and high magnetic fields. Results: Experimental results showed that DOTA-Gd-CBT-NP possesses a low r(2)/r(1) ratio 0.91 which enables it to enhance T-1 MR imaging of liver tumor at 1.0 T, and a high r(2)/r(1) ratio 11.8 which renders the nanoparticle to largely enhance T-2 MR imaging of liver tumor at 9.4 T. Conclusion: We expect that our GGT-responsive Gd-nanoparticle could be applied for simultaneous T-1 and T-2 MRI diagnosis of early liver cancer in clinic at respective low and high magnetic fields when the 9.4 T MR machine is clinically available in the future.
WOS关键词IRON-OXIDE NANOPARTICLES ; CONTRAST AGENTS ; R(2) RELAXIVITY ; GADOLINIUM
资助项目National Natural Science Foundation of China[21725505] ; National Natural Science Foundation of China[21904002] ; National Natural Science Foundation of China[22074016] ; Natural Science Foundation of Anhui Province[2008085QB94] ; Clinical Research Incubation Program of the Second Hospital of Anhui Medical University[2020LCZD18]
WOS研究方向Research & Experimental Medicine
语种英语
出版者IVYSPRING INT PUBL
WOS记录号WOS:000719152600002
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Clinical Research Incubation Program of the Second Hospital of Anhui Medical University
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/126538]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Longsheng; Liang, Gaolin
作者单位1.Anhui Univ, Inst Phys Sci & Informat Technol, Minist Educ, Key Lab Struct & Funct Regulat Hybrid Mat, Hefei 230601, Anhui, Peoples R China
2.Anhui Med Univ, Hosp 2, Dept Radiol, Hefei 230601, Anhui, Peoples R China
3.Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China
4.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Li, Huan,Hai, Zijuan,Zou, Liwei,et al. Simultaneous enhancement of T-1 and T-2 magnetic resonance imaging of liver tumor at respective low and high magnetic fields[J]. THERANOSTICS,2022,12.
APA Li, Huan.,Hai, Zijuan.,Zou, Liwei.,Zhang, Lele.,Wang, Lulu.,...&Liang, Gaolin.(2022).Simultaneous enhancement of T-1 and T-2 magnetic resonance imaging of liver tumor at respective low and high magnetic fields.THERANOSTICS,12.
MLA Li, Huan,et al."Simultaneous enhancement of T-1 and T-2 magnetic resonance imaging of liver tumor at respective low and high magnetic fields".THERANOSTICS 12(2022).

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来源：合肥物质科学研究院

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