Neoadjuvant therapy vs. upfront surgery for resectable pancreatic cancer: An update on a systematic review and meta-analysis
文献类型：期刊论文
| 作者 | Xu, Youyao1,2; Chen, Yizhen1,2; Han, Fang2; Wu, Jia2; Zhang, Yuhua2 |
| 刊名 | BIOSCIENCE TRENDS
 |
| 出版日期 | 2021-11-10 |
| 关键词 | neoadjuvant therapy resectable pancreatic neoplasm prognosis |
| ISSN号 | 1881-7815 |
| DOI | 10.5582/bst.2021.01459 |
| 通讯作者 | Zhang, Yuhua(drzhangyuhua@126.com) |
| 英文摘要 | The effectiveness of neoadjuvant therapy (NAT) remains controversial in the treatment of pancreatic cancer (PC). Therefore, this meta-analysis aimed to investigate the clinical differences between NAT and upfront surgery (US) in resectable pancreatic cancer (RPC). Eligible studies were retrieved from PubMed, Embase, and Cochrane Library. The endpoints assessed were R0 resection rate, pathological T stage < 2 rate, positive lymph node rate, and overall survival. A total of 4,588 potentially relevant studies were identified, and 13 studies were included in this study. In patients with RPC, this meta-analysis showed that NAT presented an increased R0 resection rate, pathological T stage < 2 rate, and a remarkably reduced positive lymph node rate compared to US. However, patients receiving NAT did not result in a significantly increased overall survival. These findings supported the application of NAT, especially as a patient selection strategy, in the management of RPC. Additional large clinical studies are needed to determine whether NAT is superior to US. |
| WOS关键词 | PREOPERATIVE CHEMORADIATION ; MULTIMODALITY THERAPY ; ADJUVANT THERAPY ; OPEN-LABEL ; GEMCITABINE ; ADENOCARCINOMA ; OUTCOMES ; CHEMORADIOTHERAPY ; CHEMOTHERAPY ; RESECTION |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000718558700001 |
| 出版者 | IRCA-BSSA |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/126552]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Yuhua |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Hangzhou, Zhejiang, Peoples R China 2.Chinese Acad Sci, Canc Hosp, Inst Basic Med & Canc IBMC, Univ Chinese Acad Sci,Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Youyao,Chen, Yizhen,Han, Fang,et al. Neoadjuvant therapy vs. upfront surgery for resectable pancreatic cancer: An update on a systematic review and meta-analysis[J]. BIOSCIENCE TRENDS,2021. |
| APA | Xu, Youyao,Chen, Yizhen,Han, Fang,Wu, Jia,&Zhang, Yuhua.(2021).Neoadjuvant therapy vs. upfront surgery for resectable pancreatic cancer: An update on a systematic review and meta-analysis.BIOSCIENCE TRENDS. |
| MLA | Xu, Youyao,et al."Neoadjuvant therapy vs. upfront surgery for resectable pancreatic cancer: An update on a systematic review and meta-analysis".BIOSCIENCE TRENDS (2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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