中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Analysis of Gut Microbiota Composition in Lung Adenocarcinoma Patients with TCM Qi-Yin Deficiency

文献类型：期刊论文

作者Chen, Jiabin3; Wang, Sheng4; Shen, Jianfei1; Hu, Qinqin3; Zhang, Yongjun2; Ma, Dehua1; Chai, Kequn3
刊名AMERICAN JOURNAL OF CHINESE MEDICINE
出版日期2021
卷号49
关键词Lung Adenocarcinoma Traditional Chinese Medicine Qi-Yin Deficiency Gut Microbiota Diagnostic Model
ISSN号0192-415X
DOI10.1142/S0192415X21500786
通讯作者Ma, Dehua(madh@enzemed.com) ; Chai, Kequn(ckq_official@163.com)
英文摘要In Lung adenocarcinoma (ADC), Qi-Yin deficiency syndrome (QY) is the most common Traditional Chinese medicine (TCM) syndrome. This study aimed to investigate the diversity and composition of gut microbiota in ADC patients with QY syndrome. 90 stool samples, including 30 healthy individuals (H), 30 ADC patients with QY syndrome, and 30 ADC patients with another syndrome (O) were collected. Then, 16s-RNA sequencing was used to analyze stool samples to clarify the structure of gut microbiota, and linear discriminant analysis (LDA) effect size (LEfSe) was applied to identify biomarkers for ADC with QY syndrome. Logistic regression analysis was performed to establish a diagnostic model for the diagnosis of QY syndrome in ADC patients, which was assessed with the AUC. Finally, 20 fecal samples (QY: 10; O: 10) were analyzed with Metagenomics to validate the diagnostic model. The alpha diversity and beta diversity demonstrated that the structure of gut microbiota in the QY group was different from that of the H group and O group. In the QY group, the top 3 taxonomies at phylum level were Firmicutes, Bacteroidetes, and Proteobacteria, and at genus level were Faecalibacterium, Prevotella_9, and Bifidobacterium. LEfSe identified Prevotella_9 and Streptococcus might be the biomarkers for QY syndrome. A diagnostic model was constructed using those 2 genera with the AUC = 0.801, similar to the AUC based on Metagenomics (0.842). The structure of gut microbiota in ADC patients with QY syndrome was investigated, and a diagnostic model was developed for the diagnosis of QY syndrome in ADC patients, which provides a novel idea for the understanding and diagnosis of TCM syndrome.
WOS关键词TRADITIONAL CHINESE MEDICINE ; ADJUNCTIVE THERAPY ; CANCER ; PREVOTELLA ; SURVIVAL ; INSIGHTS ; BIOLOGY
资助项目National Natural Science Foundation of China[81673781] ; Key R&D plan of Zhejiang Province[2015C03033] ; Zhejiang provincial fund for outstanding young talents of traditional Chinese Medicine[2019ZQ006]
WOS研究方向Integrative & Complementary Medicine ; General & Internal Medicine
语种英语
WOS记录号WOS:000720336900005
出版者WORLD SCIENTIFIC PUBL CO PTE LTD
资助机构National Natural Science Foundation of China ; Key R&D plan of Zhejiang Province ; Zhejiang provincial fund for outstanding young talents of traditional Chinese Medicine
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/126620]  
专题中国科学院合肥物质科学研究院
通讯作者Ma, Dehua; Chai, Kequn
作者单位1.Taizhou Hosp, Dept Thorac Surg, 150 Ximen St, Taizhou 310012, Zhejiang, Peoples R China
2.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
3.Tongde Hosp Zhejiang, Dept Oncol, 234 Gu Cui Rd, Hangzhou 310012, Zhejiang, Peoples R China
4.Jinhua Guangfu Hosp, Dept Resp, Jinhua 321000, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Jiabin,Wang, Sheng,Shen, Jianfei,et al. Analysis of Gut Microbiota Composition in Lung Adenocarcinoma Patients with TCM Qi-Yin Deficiency[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2021,49.
APA Chen, Jiabin.,Wang, Sheng.,Shen, Jianfei.,Hu, Qinqin.,Zhang, Yongjun.,...&Chai, Kequn.(2021).Analysis of Gut Microbiota Composition in Lung Adenocarcinoma Patients with TCM Qi-Yin Deficiency.AMERICAN JOURNAL OF CHINESE MEDICINE,49.
MLA Chen, Jiabin,et al."Analysis of Gut Microbiota Composition in Lung Adenocarcinoma Patients with TCM Qi-Yin Deficiency".AMERICAN JOURNAL OF CHINESE MEDICINE 49(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。