Current status of total neoadjuvant therapy for locally advanced rectal cancer
文献类型：期刊论文
| 作者 | Feng, Wei5,7; Yu, Bin1,6; Zhang, Zhenya1,6; Li, Juan2,3,4,6; Wang, Yuxiang2,3,4,6 |
| 刊名 | ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
 |
| 出版日期 | 2021-11-24 |
| 关键词 | chemoradiation therapy chemotherapy disease-free survival (DFS) pathological complete response (pCR) rectal cancer sphincter preservation |
| ISSN号 | 1743-7555 |
| DOI | 10.1111/ajco.13640 |
| 通讯作者 | Wang, Yuxiang(wyxhbs69@163.com) |
| 英文摘要 | Neoadjuvant chemoradiotherapy (nCRT) plus total mesorectal excision (TME) has been the standard regimen for treatment of patients with locally advanced rectal cancer (LARC), because it significantly reduces the rate of local recurrence and enables sphincter preservation. However, distant metastasis remains the major reason for treatment failure, and the value of postoperative chemotherapy is still controversial. Recent studies have examined the use of total neoadjuvant therapy (TNT), defined as induction and/or consolidation chemotherapy (CONCT) with radiotherapy (RT) or nCRT prior to surgery. The results indicated that TNT may increase the rates of chemotherapy compliance and pathological complete response (pCR), and probably improve the success rate of sphincter preservation surgery. TNT may also improve disease-free survival and overall survival, and even reduce the rate of relapse. Here, we critically appraise the existing literature on three different TNT schemes used for LARC patients. |
| WOS关键词 | TOTAL MESORECTAL EXCISION ; PHASE-III TRIAL ; HIGH-RISK ; PREOPERATIVE CHEMORADIOTHERAPY ; OPEN-LABEL ; INDUCTION CHEMOTHERAPY ; ADJUVANT CHEMOTHERAPY ; RADIATION-THERAPY ; POSTOPERATIVE CHEMORADIOTHERAPY ; CONCOMITANT CHEMORADIOTHERAPY |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000721908300001 |
| 出版者 | WILEY |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/126666]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Yuxiang |
| 作者单位 | 1.Hebei Med Univ, Dept Surg 2, Affiliated Hosp 4, Shijiazhuang, Hebei, Peoples R China 2.Hebei Med Univ, Affiliated Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China 3.Hebei Clin Res Ctr Radiat Oncol, Shijiazhuang 050011, Hebei, Peoples R China 4.Hebei Med Univ, Dept Radiat Oncol, Affiliated Hosp 4, Shijiazhuang, Hebei, Peoples R China 5.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Hangzhou, Peoples R China 6.Hebei Prov Tumor Hosp, Shijiazhuang 050011, Hebei, Peoples R China 7.Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Wei,Yu, Bin,Zhang, Zhenya,et al. Current status of total neoadjuvant therapy for locally advanced rectal cancer[J]. ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY,2021. |
| APA | Feng, Wei,Yu, Bin,Zhang, Zhenya,Li, Juan,&Wang, Yuxiang.(2021).Current status of total neoadjuvant therapy for locally advanced rectal cancer.ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. |
| MLA | Feng, Wei,et al."Current status of total neoadjuvant therapy for locally advanced rectal cancer".ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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