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Menstrual factors, reproductive history, and risk of lung cancer: a multi-center population-based cohort study in Chinese females

文献类型：期刊论文

作者Yang, Zhuoyu11; Wang, Fei11; Tan, Fengwei12; Cao, Wei11; Xu, Yongjie11; Qin, Chao11; Yu, Yiwen11; Zhao, Liang11; Wen, Yan11; Wu, Zheng11
刊名TRANSLATIONAL LUNG CANCER RESEARCH
出版日期2021-10-01
卷号10
关键词Lung cancer hormones population-based cohort study
ISSN号2218-6751
DOI10.21037/tlcr-21-552
通讯作者Li, Ni(nli@cicams.ac.cn) ; He, Jie(prof.jiehe@gmail.com)
英文摘要Background: Female menstrual and reproductive factors, as remarkable indicators of hormone effect, were hypothesized to be associated with lung cancer risk, whereas the existed epidemiological evidence was inconsistent. Our study aims to investigate the association between menstrual and reproductive factors and lung cancer risk based on the Chinese Lung Cancer Screening Program. Methods: This study was based on a large-scale multi- center population cohort across China recruiting individuals aged 40-74 years old between 2013-2018. Cox regression model was applied to estimate the HRs and 95% CIs. Restricted cubic spline (RCS) analysis was used to estimate dose-response relationships and test for nonlinear associations. Results: Among 553,434 female participants, 1,529 incident lung cancer cases were identified with a median follow-up of 3.61 years. With adjustment for multiple covariates and all significant hormonal factors, elevated lung cancer risk was associated with later age (15, or >= 16 years) at menarche (HR=1.27, 95% CI: 1.04-1.56; HR=1.45, 95% CI: 1.19-1.76), later age (25-29, or >= 30 years) at first live birth (HR=1.27, 95% CI: 1.13-1.43; HR=1.23, 95% CI: 1.00-1.51), and benign breast disease history (HR=1.25, 95% CI: 1.101.41). For postmenopausal females specifically, surgical menopause (HR=1.62; 95% CI: 1.29-2.05) and other surgeries on the reproductive system (HR=1.19; 95% CI: 1.01-1.40) both appeared to be predictive of elevated lung cancer risk. Concerning age at menopause, a nonlinear association was observed (P-nonlinear=0.0126). Increased lung cancer risk was observed among females with age at menopause especially above 50. Although we observed no significant associations between longer time (>= 13 months) of breastfeeding and lung cancer risk among all participants (HR=0.86; 95% CI: 0.71- 1.04), significant decreased adenocarcinoma risk (HR=0.65; 95% CI: 0.53-0.81) was noted among nonsmoking females. Conclusions: Our findings add some support for the role of menstrual and reproductive factors in lung carcinogenesis. However, these relationships were complex, and required further investigations addressing the biological mechanisms.
WOS关键词HORMONAL FACTORS ; WOMENS-HEALTH ; ESTROGEN ; SINGAPORE ; SMOKING ; SOY ; EXPRESSION ; RECEPTORS ; SHANGHAI ; DIET
资助项目Ministry of Finance of the People's Republic of China ; National Health Commission of the People's Republic of China ; National Key Research & Development Program of China[2018YFC1315000/2018YFC1315001] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2019PT320027] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2020PT330001] ; CAMS Innovation Fund for Medical Science[2019-I2M-2-002] ; Sanming Project of Medicine in Shenzhen[SZSM201911015] ; National Natural Science Foundation of China[8187102812] ; Beijing Science and Technology Project[Z181100001718212] ; Medical Sciences and Peking Union Medical College[IRB:15-070/997]
WOS研究方向Oncology ; Respiratory System
语种英语
WOS记录号WOS:000710739500001
出版者AME PUBL CO
资助机构Ministry of Finance of the People's Republic of China ; National Health Commission of the People's Republic of China ; National Key Research & Development Program of China ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences ; CAMS Innovation Fund for Medical Science ; Sanming Project of Medicine in Shenzhen ; National Natural Science Foundation of China ; Beijing Science and Technology Project ; Medical Sciences and Peking Union Medical College
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/126702]  
专题中国科学院合肥物质科学研究院
通讯作者Li, Ni; He, Jie
作者单位1.Anhui Prov Canc Hosp, Canc Dept Phys Examinat, Hefei, Peoples R China
2.Xuzhou Canc Hosp, Off Canc Prevent & Treatment, Xuzhou, Jiangsu, Peoples R China
3.Guangxi Med Univ, Dept Expt Pathol, Tumor Hosp, Nanning, Peoples R China
4.Zhengzhou Univ, Henan Engn Res Ctr Canc Prevent & Control, Henan Int Joint Lab Canc Prevent,Henan Engn Res C, Dept Canc Epidemiol,Affiliated Canc Hosp,Henan Ca, Zhengzhou, Henan, Peoples R China
5.Cent South Univ, Hunan Canc Hosp, Dept Canc Prevent & Control, Changsha, Peoples R China
6.Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Peoples R China
7.Peking Univ, Key Lab Carcinogenesis & Translat Res, Beijing Off Canc Prevent & Control, Minist Educ Beijing,Canc Hosp & Inst, Beijing, Peoples R China
8.Chinese Acad Med Sci, Key Lab Natl Canc Big Data Anal & Implement, Beijing, Peoples R China
9.Univ Chinese Acad Sci, Chinese Acad Sci, Dept Canc Prevent, Canc Hosp,Zhejiang Canc Hosp,IBMC, Hangzhou, Peoples R China
10.Nanjing Med Univ, Jiangsu Collaborat Innovat Ctr Canc Personalized, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Zhuoyu,Wang, Fei,Tan, Fengwei,et al. Menstrual factors, reproductive history, and risk of lung cancer: a multi-center population-based cohort study in Chinese females[J]. TRANSLATIONAL LUNG CANCER RESEARCH,2021,10.
APA Yang, Zhuoyu.,Wang, Fei.,Tan, Fengwei.,Cao, Wei.,Xu, Yongjie.,...&He, Jie.(2021).Menstrual factors, reproductive history, and risk of lung cancer: a multi-center population-based cohort study in Chinese females.TRANSLATIONAL LUNG CANCER RESEARCH,10.
MLA Yang, Zhuoyu,et al."Menstrual factors, reproductive history, and risk of lung cancer: a multi-center population-based cohort study in Chinese females".TRANSLATIONAL LUNG CANCER RESEARCH 10(2021).

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来源：合肥物质科学研究院

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