Non-Coding RNAs as Circulating Biomarkers for the Diagnosis of Intracranial Aneurysm: A Systematic Review and Meta- Analysis
文献类型：期刊论文
| 作者 | Wu, Yuehui3; Zheng, Jin3; Sun, Yun3; Wang, Xuan3; Zhao, Hongyang3; Qiu, Feng3; Zhang, Shuyuan1,2,4; Jiang, Xiaobing3; Yu, Xinyu3 |
| 刊名 | JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
 |
| 出版日期 | 2021-06-01 |
| 卷号 | 30 |
| ISSN号 | 1052-3057 |
| 关键词 | Intracranial aneurysm Non-coding RNA Diagnosis Meta-analysis |
| DOI | 10.1016/j.jstrokecerebrovasdis.2021.105762 |
| 通讯作者 | Jiang, Xiaobing(jxb917@126.com) ; Yu, Xinyu(yuxinyu7@hust.edu.cn) |
| 英文摘要 | Background: Early diagnosis of intracranial aneurysm (IA) is arduous in the current situation, and no biomarker is available for the screening of IA. We here systemati-cally evaluate the diagnostic value of circulating non-coding RNA (ncRNA) for the diagnosis of IA. Methods: We searched PubMed, Web of Science, Embase, Scopus and Cochrane Library databases from inception to June 2020. We included studies that investigated the diagnostic performance of circulating ncRNAs for the diagno-sis of IA. We performed Random-effect meta-analyses for the diagnostic test accu-racy to calculate pooled estimates. Subgroup analyses and sensitivity analyses were conducted to explore the source of heterogeneity. Results: Thirteen studies, includ-ing 1,105 patients and 28 ncRNAs, were included. The pooled sensitivity and speci-ficity were 0.80 (95% confidence interval [CI], 0.76-0.83) and 0.80 (95% CI, 0.76-0.84), respectively, and the area under the hierarchical summary receiver operating characteristic curve was 0.87 (95% CI, 0.84-0.89). The pooled positive and negative likelihood ratios were 3.97 (95% CI, 3.17-4.98) and 0.25 (95% CI, 0.21-0.31), corre-sponding with a diagnostic odds ratio of 15.63 (95% CI, 10.41-23.47). Subgroup analyses revealed that the diagnostic accuracy of miRNA, lncRNA and circRNA were not significantly different (p > 0.05). Circulating ncRNAs showed higher diag-nostic accuracy for patients with unruptured IA than those with ruptured IA (p = 0.0122). Conclusion: Current evidence suggests that the circulating ncRNA test could be an effective method for universal IA screening. Future clinical studies need to confirm the diagnostic role of specific ncRNAs. |
| WOS关键词 | SMOOTH-MUSCLE-CELLS ; SUBARACHNOID HEMORRHAGE ; POTENTIAL BIOMARKER ; PROLIFERATION ; EXPRESSION ; RUPTURE ; CANCER ; BLOOD ; SEX ; AGE |
| WOS研究方向 | Neurosciences & Neurology ; Cardiovascular System & Cardiology |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000717466500034 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/126704]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Jiang, Xiaobing; Yu, Xinyu |
| 作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Dept Neurosurg, Hangzhou 310022, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Neurosurg, 1277 Jiefang Ave, Wuhan 430022, Peoples R China 4.Zhejiang Canc Hosp, Dept Neurosurg, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yuehui,Zheng, Jin,Sun, Yun,et al. Non-Coding RNAs as Circulating Biomarkers for the Diagnosis of Intracranial Aneurysm: A Systematic Review and Meta- Analysis[J]. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,2021,30. |
| APA | Wu, Yuehui.,Zheng, Jin.,Sun, Yun.,Wang, Xuan.,Zhao, Hongyang.,...&Yu, Xinyu.(2021).Non-Coding RNAs as Circulating Biomarkers for the Diagnosis of Intracranial Aneurysm: A Systematic Review and Meta- Analysis.JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,30. |
| MLA | Wu, Yuehui,et al."Non-Coding RNAs as Circulating Biomarkers for the Diagnosis of Intracranial Aneurysm: A Systematic Review and Meta- Analysis".JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 30(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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