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Effect of donor characteristics on T cell-replete haploidentical stem cell transplantation over the last 10 years at a single institution

文献类型：期刊论文

作者Wu, Yibo1,4,5,6; Lai, Xiaoyu1,4,5,6; Shi, Jimin1,4,5,6; Tan, Yamin3; Zhao, Yanmin1,4,5,6; Yu, Jian1,4,5,6; Liu, Lizhen1,4,5,6; Zhang, Wei2; Huang, He1,4,5,6; Luo, Yi1,4,5,6
刊名BRITISH JOURNAL OF HAEMATOLOGY
出版日期2021-12-03
ISSN号0007-1048
关键词haploidentical haematopoietic stem cell transplantation donor selection donor characteristics donor age female to male
DOI10.1111/bjh.17978
通讯作者Huang, He(huanghe@zju.edu.cn) ; Luo, Yi(luoyijr@zju.edu.cn)
英文摘要One of the most complex issues with haploidentical stem cell transplantation (haplo-SCT) is donor selection, given that multiple haploidentical donors are often available for a given recipient. To develop evidence-based guidance for donor selection in the setting of anti-thymocyte globulin-based haplo-SCT, we performed a prospective cohort study of 512 patients with haematological malignancies who had haplo-SCT to determine which donor variables were most important in favouring transplant outcomes. Increasing donor age was associated with poorer overall survival (OS) [hazard ratio (HR) 1 center dot 08, P = 0 center dot 044]. Female donors to male recipients was significantly associated with higher non-relapse mortality (NRM; HR 2 center dot 05, P = 0 center dot 006). Furthermore, increasing donor age had a higher risk of Grades 3-4 acute graft-versus-host disease (aGVHD; HR 1 center dot 17, P = 0 center dot 005), female donors to male recipients was associated with a higher risk of Grades 2-4 aGVHD (HR 1 center dot 50, P = 0 center dot 022). Sibling donors had superior OS, disease-free survival, and NRM than parental donors in patients aged <35 years. However, sibling donors had higher NRM than offspring donors in patients aged >= 35 years. A younger donor, usually a young sibling in younger recipients (aged <35 years) or a young offspring in older patients (aged >= 35 years) and avoiding female donors to male recipients should be preferred when multiple haploidentical donors are available.
WOS关键词BONE-MARROW-TRANSPLANTATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; ACUTE MYELOID-LEUKEMIA ; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE ; HEMATOLOGIC MALIGNANCIES ; ABO INCOMPATIBILITY ; PEDIATRIC-PATIENTS ; HLA DISPARITY ; OUTCOMES ; DISEASE
资助项目National Key Research and Development Program of China[2018YFA0107804] ; China's National Natural Science Foundation[81970158]
WOS研究方向Hematology
语种英语
出版者WILEY
WOS记录号WOS:000725471700001
资助机构National Key Research and Development Program of China ; China's National Natural Science Foundation
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/126782]  
专题中国科学院合肥物质科学研究院
通讯作者Huang, He; Luo, Yi
作者单位1.Zhejiang Prov Engn Lab Stem Cell & Immun Therapy, Hangzhou, Peoples R China
2.Blood Ctr Zhejiang Prov, HLA Typing Lab, Hangzhou, Peoples R China
3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Beijing, Peoples R China
4.Zhejiang Univ, Med Ctr, Liangzhu Lab, Hangzhou, Peoples R China
5.Zhejiang Univ, Inst Hematol, Hangzhou, Peoples R China
6.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Bone Marrow Transplantat Ctr, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Yibo,Lai, Xiaoyu,Shi, Jimin,et al. Effect of donor characteristics on T cell-replete haploidentical stem cell transplantation over the last 10 years at a single institution[J]. BRITISH JOURNAL OF HAEMATOLOGY,2021.
APA Wu, Yibo.,Lai, Xiaoyu.,Shi, Jimin.,Tan, Yamin.,Zhao, Yanmin.,...&Luo, Yi.(2021).Effect of donor characteristics on T cell-replete haploidentical stem cell transplantation over the last 10 years at a single institution.BRITISH JOURNAL OF HAEMATOLOGY.
MLA Wu, Yibo,et al."Effect of donor characteristics on T cell-replete haploidentical stem cell transplantation over the last 10 years at a single institution".BRITISH JOURNAL OF HAEMATOLOGY (2021).

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来源：合肥物质科学研究院

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