Urinary Exosomes Diagnosis of Urological Tumors: A Systematic Review and Meta-Analysis
文献类型：期刊论文
| 作者 | Xu, Yipeng3; Lou, Jianmin4; Yu, Mingke4; Jiang, Yingjun2; Xu, Han5; Huang, Yueyu4; Gao, Yun6,7; Wang, Hua3 ; Li, Guorong1,8; Wang, Zongping3
|
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2021-09-10 |
| 卷号 | 11 |
| 关键词 | urological tumor exosomes urine diagnosis liquid biopsy |
| ISSN号 | 2234-943X |
| DOI | 10.3389/fonc.2021.734587 |
| 通讯作者 | Wang, Zongping() ; Zhao, An() |
| 英文摘要 | Purpose: Exosomes could be released directly into the urine by the urological tumoral cells, so testing urinary exosomes has great potential for non-invasive diagnosis and monitor of urological tumors. The objective of this study is to systematically review and meta-analysis of urinary exosome for urological tumors diagnosis.& nbsp;Materials and Methods: A systematic review of the recent English-language literature was conducted according to the PRISMA statement recommendations (CRD42021250613) using PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases up to April 30, 2021. Risk-of-bias assessment was performed according to the QUADAS 2 tool. The true diagnostic value of urinary exosomes by calculating the number of true positive, false positive, true negative, and false negative, diagnoses by extracting specificity and sensitivity data from the selected literature.& nbsp;Results: Sixteen eligible studies enrolling 3224 patients were identified. The pooled sensitivity and specificity of urinary exosomes as a diagnostic tool in urological tumors were 83% and 88%, respectively. The area under the summary receiver operating characteristic curve was 0.92 (95% CI: 0.89-0.94). Further subgroup analyses showed that our results were stable irrespective of the urinary exosome content type and tumor type.& nbsp;Conclusion: Urinary exosomes may serve as novel non-invasive biomarkers for urological cancer detection. Future clinical trial designs must validate and explore their utility in treatment decision-making.& nbsp; |
| WOS关键词 | PROSTATE-CANCER ; EXTRACELLULAR VESICLES ; BIOMARKERS ; COMMUNICATION ; EXPRESSION ; CARCINOMA ; UTILITY |
| 资助项目 | National Natural Science Foundation of China[81402117] ; Natural Science Foundation of Zhejiang Province[LY17H160043] ; Medical and Health Project of Zhejiang Province[2016KYA038] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000724602000001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Zhejiang Province ; Medical and Health Project of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/126802]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Zongping; Zhao, An |
| 作者单位 | 1.Univ Jean Monnet, Fac Med, INSERM, U1059, St Etienne, France 2.Zhejiang Chinese Med Univ, Hangzhou Tradit Chinese Med Hosp, Hangzhou, Zhejiang, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Urol, Canc Hosp, Hangzhou, Zhejiang, Peoples R China 4.Zhejiang Chinese Med Univ, Hangzhou, Zhejiang, Peoples R China 5.Nanchang Univ, Childrens Hosp, Cent Res Lab, Nanchang, Jiangxi, Peoples R China 6.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Expt Res Ctr, Hangzhou, Zhejiang, Peoples R China 7.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Zhejiang, Peoples R China 8.Univ Jean Monnet, CHU St Etienne, North Hosp, Dept Urol, St Etienne, France |
| 推荐引用方式 GB/T 7714 | Xu, Yipeng,Lou, Jianmin,Yu, Mingke,et al. Urinary Exosomes Diagnosis of Urological Tumors: A Systematic Review and Meta-Analysis[J]. FRONTIERS IN ONCOLOGY,2021,11. |
| APA | Xu, Yipeng.,Lou, Jianmin.,Yu, Mingke.,Jiang, Yingjun.,Xu, Han.,...&Zhao, An.(2021).Urinary Exosomes Diagnosis of Urological Tumors: A Systematic Review and Meta-Analysis.FRONTIERS IN ONCOLOGY,11. |
| MLA | Xu, Yipeng,et al."Urinary Exosomes Diagnosis of Urological Tumors: A Systematic Review and Meta-Analysis".FRONTIERS IN ONCOLOGY 11(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。